The Hedgehog signal transduction network
Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …
and adult structures, and disruption of Hh signaling pathways results in various human …
G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling
The hedgehog (Hh) signalling pathway has an evolutionarily conserved role in patterning
fields of cells during metazoan development, and is inappropriately activated in cancer 1 , 2 . …
fields of cells during metazoan development, and is inappropriately activated in cancer 1 , 2 . …
[HTML][HTML] Wild-type U2AF1 antagonizes the splicing program characteristic of U2AF1-mutant tumors and is required for cell survival
We have asked how the common S34F mutation in the splicing factor U2AF1 regulates
alternative splicing in lung cancer, and why wild-type U2AF1 is retained in cancers with this …
alternative splicing in lung cancer, and why wild-type U2AF1 is retained in cancers with this …
Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma
Esophageal adenocarcinoma ranks sixth in cancer mortality in the world and its incidence has
risen dramatically in the Western population over the last decades. Data presented herein …
risen dramatically in the Western population over the last decades. Data presented herein …
[HTML][HTML] Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study
Background Epidemiologic studies and animal models suggest that in utero arsenic exposure
affects fetal health, with a negative association between maternal arsenic ingestion and …
affects fetal health, with a negative association between maternal arsenic ingestion and …
In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort
Arsenic has wide-ranging effects on human health and there is evidence that it alters the
immune response by influencing CD4 +/CD8 + T cell ratios, IL-2 cytokine levels, and the …
immune response by influencing CD4 +/CD8 + T cell ratios, IL-2 cytokine levels, and the …
The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation
Somatic mutations in the genes encoding components of the spliceosome occur frequently
in human neoplasms, including myeloid dysplasias and leukemias, and less often in solid …
in human neoplasms, including myeloid dysplasias and leukemias, and less often in solid …
Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1
DL Fei, T Zhen, B Durham… - Proceedings of the …, 2018 - National Acad Sciences
Mutations affecting the spliceosomal protein U2AF1 are commonly found in myelodysplastic
syndromes (MDS) and secondary acute myeloid leukemia (sAML). We have generated mice …
syndromes (MDS) and secondary acute myeloid leukemia (sAML). We have generated mice …
Pyrvinium attenuates Hedgehog signaling downstream of smoothened
The Hedgehog (HH) signaling pathway represents an important class of emerging developmental
signaling pathways that play critical roles in the genesis of a large number of human …
signaling pathways that play critical roles in the genesis of a large number of human …
[HTML][HTML] Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis
Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote
aberrant activation of the WNT pathway that is responsible for APC-associated diseases …
aberrant activation of the WNT pathway that is responsible for APC-associated diseases …