Kynurenine pathway in skin cells: Implications for UV-induced skin damage
D Sheipouri, N Braidy… - International Journal of …, 2012 - journals.sagepub.com
The kynurenine pathway (KP) is the principle route of catabolism of the essential amino acid
tryptophan, leading to the production of several neuroactive and immunoregulatory …
tryptophan, leading to the production of several neuroactive and immunoregulatory …
[HTML][HTML] Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q
…, DJ Fazakerley, C Suarna, GJ Maghzal, D Sheipouri… - Redox biology, 2021 - Elsevier
Mitochondrial energy production and function rely on optimal concentrations of the essential
redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction …
redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction …
[HTML][HTML] Role of myeloperoxidase oxidants in the modulation of cellular lysosomal enzyme function: a contributing factor to macrophage dysfunction in atherosclerosis …
FO Ismael, TJ Barrett, D Sheipouri, BE Brown… - PloS one, 2016 - journals.plos.org
Low-density lipoprotein (LDL) is the major source of lipid within atherosclerotic lesions.
Myeloperoxidase (MPO) is present in lesions and forms the reactive oxidants hypochlorous acid (…
Myeloperoxidase (MPO) is present in lesions and forms the reactive oxidants hypochlorous acid (…
Characterisation of the kynurenine pathway in skin‐derived fibroblasts and keratinocytes
D Sheipouri, R Grant, S Bustamante… - Journal of cellular …, 2015 - Wiley Online Library
Acute UVB exposure triggers inflammation leading to the induction of indoleamine 2,3
dioxygenase (IDO1), one of the first enzymes in the kynurenine pathway (KP) for tryptophan …
dioxygenase (IDO1), one of the first enzymes in the kynurenine pathway (KP) for tryptophan …
[HTML][HTML] A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors
D Sheipouri, CI Gallagher, S Shimmon, T Rawling… - Biomolecules, 2020 - mdpi.com
Reduced inhibitory glycinergic neurotransmission is implicated in a number of neurological
conditions such as neuropathic pain, schizophrenia, epilepsy and hyperekplexia. Restoring …
conditions such as neuropathic pain, schizophrenia, epilepsy and hyperekplexia. Restoring …
MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia
…, E Meyer, J Zhen, H Hirata, D Sheipouri… - Movement …, 2022 - Wiley Online Library
Background Despite advances in next generation sequencing technologies, the identification
of variants of uncertain significance (VUS) can often hinder definitive diagnosis in patients …
of variants of uncertain significance (VUS) can often hinder definitive diagnosis in patients …
Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors
CI Gallagher, D Sheipouri, S Shimmon… - Biochemical …, 2020 - Elsevier
Glycine receptors (GlyRs) mediate inhibitory neurotransmission within the spinal cord and
play a crucial role in nociceptive signalling. This makes them primary targets for the …
play a crucial role in nociceptive signalling. This makes them primary targets for the …
Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2
CI Gallagher, ZJ Frangos, D Sheipouri… - ACS Chemical …, 2023 - ACS Publications
Chronic pain is a complex condition that remains resistant to current therapeutics. We previously
synthesized a series of N-acyl amino acids (NAAAs) that inhibit the glycine transporter, …
synthesized a series of N-acyl amino acids (NAAAs) that inhibit the glycine transporter, …
Glycine receptors are not directly modulated by glutamate, AP5 or NMDA
K Aubrey, D Sheipouri, R Vandenberg, Y Otsu - bioRxiv, 2020 - biorxiv.org
3. Abstract Reproducibility of research data is a significant problem with more than 60% of
biological and medical researchers reporting they have failed to reproduce published data. …
biological and medical researchers reporting they have failed to reproduce published data. …
Glutamate, d-(−)-2-Amino-5-Phosphonopentanoic Acid, and N-Methyl-d-Aspartate Do Not Directly Modulate Glycine Receptors
Replication studies play an essential role in corroborating research findings and ensuring
that subsequent experimental works are interpreted correctly. A previously published paper …
that subsequent experimental works are interpreted correctly. A previously published paper …