Nucleotides are ubiquitous intercellular messengers whose actions are mediated by specific
receptors. Since the first clonings in 1993, it is known that nucleotide receptors belong to …

Therapeutic angiogenesis is likely to require the administration of factors that complement
each other. Activation of the receptor tyrosine kinase (RTK) Flk1 by vascular endothelial …

The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of
secretory granules (such as platelet dense granules), or efflux through membrane channels. …

Clones encoding a new human P2Y receptor, provisionally called P2Y 11 , have been
isolated from human placenta complementary DNA and genomic DNA libraries. The 1113-base …

In order to isolate new subtypes of P2Y purinoceptors, a human placenta cDNA library was
screened at middle stringency with a P2Y 4 probe. The purification and the sequencing of …

We have cloned and expressed a novel human G-protein-coupled receptor closely related
to the human P2Y 12 receptor. It corresponds to the orphan receptor called GPR86. GPR86 …

The human P2Y 11 receptor is coupled to both the phosphoinositide and the cyclic AMP
pathways. A pharmacological characterization of the recombinant human P2Y 11 receptor has …

The P2Y 13 receptor has recently been identified as a new P2Y receptor sharing a high
sequence homology with the P2Y 12 receptor as well as similar functional properties: coupling …

In order to isolate new subtypes of P 2 purinoceptors, sets of degenerate oligonucleotide
primers were synthesized on the basis of the best conserved segments in the published …

Adenosine triphosphate has previously been shown to induce semi‐mature human
monocyte‐derived dendritic cells (DC). These are characterized by the up‐regulation of co‐…