We have detected nuclear localization signals within the 795 amino acid rat glucocorticoid
receptor. Using a transient expression assay, we monitored by immunofluorescence the …

SIGNALLING by steroid hormones is mediated by receptor proteins that bind hormonal ligands
and regulate the transcription of specific genes. The heat-shock protein hsp90 seems to …

Heat-shock protein 90 (Hsp90) is an abundant and highly conserved molecular chaperone
that is essential for viability in eukaryotes. Hsp90 fulfills a housekeeping function in …

THE human proto-oncogene myc encodes a nuclear phosphoprotein whose primary biochemical
function is still unknown 1,2 . To facilitate further study of that function, we have created …

A growing body of evidence concerning estrogen effects cannot be explained by the classic
model of hormone action, which involves the binding to estrogen receptors (ERs) α and ERβ …

The glucocorticoid receptor is a known regulator of a variety of physiological processes. Its
mode of action is well defined: upon hormone binding, it undergoes a conformational change, …

Steroid hormones such as estrogens are known to signal through ligand-regulated transcription
factors of the nuclear receptor superfamily. In addition, they elicit rapid nongenomic …

Hsp90 is required for the normal activity of steroid receptors, and in steroid receptor complexes
it is typically bound to one of the immunophilin‐related co‐chaperones: the peptidylprolyl …

The growth of both normal and transformed epithelial cells of the female reproductive
system is stimulated by estrogens, mainly through the activation of estrogen receptor α (ERα), …

The steroid hormone oestrogen can signal through several receptors and pathways. Although
the transcriptional responses mediated by the nuclear oestrogen receptors (ER) have …