Publisher Summary This chapter focuses on neuregulins (NRGs) that are the signaling proteins
that mediate cell–cell interactions in the nervous system, heart, breast, and other organ …

The signals that determine whether axons are ensheathed or myelinated by Schwann cells
have long been elusive. We now report that threshold levels of neuregulin-1 (NRG1) type III …

Motor neurons stimulate their postsynaptic muscle targets to synthesize neurotransmitter
receptors. Polypeptide signaling molecules may mediate this inductive interaction. Here we …

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor
1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a …

Glucocorticoids are potent anti-inflammatory and immunosuppressant agents. However,
they also produce serious side effects that limit their usage. It has been proposed that anti-…

The synthesis and biological evaluation of novel 3-amino indazole melanin concentrating
hormone receptor-1 antagonists are reported, several of which demonstrated functional …

4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2-one (7) is a
potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that …

A highly potent and selective DGAT-1 inhibitor was identified and used in rodent models of
obesity and postprandial chylomicron excursion to validate DGAT-1 inhibition as a novel …

… Souers a , Christopher Blackburn b , Jennifer Lee Che b , Sujen Lai b , Sevan Brodjian a
, Doug H. Falls a , Brian D. Dayton a , Elizabeth Govek b , Tom Daniels b , Brad Geddes b …

Synthesis and structure–activity relationships of isoxazole carboxamides as growth hormone
secretagogue receptor antagonists - ScienceDirect Skip to main contentSkip to article Elsevier …