Background Microglia provide continuous immune surveillance of the CNS and upon activation
rapidly change phenotype to express receptors that respond to chemoattractants during …

BACKGROUND AND PURPOSE Endometriosis is a disorder in which the endometrium forms
growths outside the uterus and is associated with chronic pain. Recent evidence suggests …

Here, we show a novel pharmacology for inhibition of human neutrophil migration by
endocannabinoids, phytocannabinoids, and related compounds. The endocannabinoids …

Background Cannabinoids are known to reduce intestinal inflammation. Atypical cannabinoids
produce pharmacological effects via unidentified targets. We were interested in whether …

A family of endogenous lipids, structurally analogous to the endogenous cannabinoid, N-arachidonoyl
ethanolamine (Anandamide), and called N-acyl amides have emerged as a …

N-arachidonoyl glycine is an endogenous arachidonoyl amide that activates the orphan G
protein-coupled receptor (GPCR) GPR18 in a pertussis toxin (PTX)-sensitive manner and …

Chronic alcohol exposure leads to significant changes in the levels of endocannabinoids
and their receptors in the brains of humans and laboratory animals, as well as in cultured …

Microglial cells are extremely plastic and undergo a variety of CNS-prompted shape changes
relative to their location and current role. Signaling molecules from neurons also regulate …

A large and growing family of over 70 endogenous lipids of the basic structure N-acyl amide
has been identified during the last 10 years. Only a few of these lipids have been …

Neurons are known to employ the endogenous cannabinoid system to communicate with
other cells of the CNS. Endocannabioid signaling recruits microglia toward neurons by …