Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update
…, CA Prows, ED Kharasch… - Clinical …, 2014 - Wiley Online Library
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450
2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity…
2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity…
[HTML][HTML] Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC®) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants …
…, K Shimoda, JR Bishop, ED Kharasch… - Clinical …, 2017 - ncbi.nlm.nih.gov
CYP2D6 and CYP2C19 polymorphisms affect the exposure, efficacy and safety of tricyclic
antidepressants (TCAs), with some drugs being affected by CYP2D6 only (eg, nortriptyline …
antidepressants (TCAs), with some drugs being affected by CYP2D6 only (eg, nortriptyline …
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants
…, CF Thorn, K Sangkuhl, ED Kharasch… - Clinical …, 2013 - Wiley Online Library
Polymorphisms in CYP2D6 and CYP2C19 affect the efficacy and safety of tricyclics, with
some drugs being affected by CYP2D6 only, and others by both polymorphic enzymes. …
some drugs being affected by CYP2D6 only, and others by both polymorphic enzymes. …
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype
…, DD Shen, JT Callaghan, ED Kharasch… - Clinical …, 2012 - Wiley Online Library
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome
P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine as an analgesic are governed …
P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine as an analgesic are governed …
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy
…, R Huddart, KE Caudle, ED Kharasch… - Clinical …, 2021 - Wiley Online Library
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized
to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone…
to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone…
Psychedelic Effects of Ketamine in Healthy Volunteers Relationship to Steady-state Plasma Concentrations
…, AD Radant, DS Cowley, ED Kharasch… - The Journal of the …, 1998 - pubs.asahq.org
Background Ketamine has been associated with a unique spectrum of subjective "psychedelic"
effects in patients emerging from anesthesia. This study quantified these effects of …
effects in patients emerging from anesthesia. This study quantified these effects of …
Nasal administration of opioids for pain management in adults
…, R Hjortkjaer, ED Kharasch - Acta anaesthesiologica …, 2002 - Wiley Online Library
Background: Nasal administration of opioids may be an alternative route to intravenous,
subcutaneous, oral transmucosal, oral or rectal administration in some patients. Key features …
subcutaneous, oral transmucosal, oral or rectal administration in some patients. Key features …
Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation
PT Manyike, ED Kharasch, TF Kalhorn… - Clinical …, 2000 - Wiley Online Library
Background CYP2E1, 1A2, and 3A4 have all been implicated in the formation of N‐acetyl‐p‐benzoquinone
imine (NAPQI), the reactive intermediate of acetaminophen (INN, …
imine (NAPQI), the reactive intermediate of acetaminophen (INN, …
Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.
ED Kharasch, KE Thummel - Anesthesiology, 1993 - europepmc.org
Background Renal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused
by biotransformation to toxic metabolites. Metabolism also contributes significantly to the …
by biotransformation to toxic metabolites. Metabolism also contributes significantly to the …
Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions
…, MF Paine, KE Thummel, ED Kharasch - Drug Metabolism and …, 1997 - ASPET
The synthetic opioid fentanyl undergoes extensive metabolism in humans. Systemic
elimination occurs primarily by hepatic metabolism. When administered as a lozenge for oral …
elimination occurs primarily by hepatic metabolism. When administered as a lozenge for oral …