[HTML][HTML] PredictSNP: robust and accurate consensus classifier for prediction of disease-related mutations

…, O Salanda, A Pavelka, ED Wieben… - PLoS computational …, 2014 - journals.plos.org
Single nucleotide variants represent a prevalent form of genetic variation. Mutations in the
coding regions are frequently associated with the development of various genetic diseases. …

[HTML][HTML] The genomic landscape of small intestine neuroendocrine tumors

…, R Tentu, BW Eckloff, ED Wieben… - The Journal of …, 2013 - Am Soc Clin Investig
Small intestine neuroendocrine tumors (SI-NETs) are the most common malignancy of the
small bowel. Several clinical trials target PI3K/Akt/mTOR signaling; however, it is unknown …

Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time—using genomic data to individualize treatment protocol

…, CRR Vitek, MS Ellingson, ED Wieben… - Mayo Clinic …, 2014 - Elsevier
Objective To report the design and implementation of the Right Drug, Right Dose, Right
Time—Using Genomic Data to Individualize Treatment protocol that was developed to test the …

Discovery of recurrent t (6; 7)(p25. 3; q32. 3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing

…, JC Porcher, N Özsan, ED Wieben… - Blood, The Journal …, 2011 - ashpublications.org
The genetics of peripheral T-cell lymphomas are poorly understood. The most well-characterized
abnormalities are translocations involving ALK, occurring in approximately half of …

[HTML][HTML] A Common Trinucleotide Repeat Expansion within the Transcription Factor 4 (TCF4, E2-2) Gene Predicts Fuchs Corneal Dystrophy

ED Wieben, RA Aleff, N Tosakulwong, ML Butz… - PLoS …, 2012 - journals.plos.org
Fuchs endothelial corneal dystrophy (FECD) is a common, familial disease of the corneal
endothelium and is the leading indication for corneal transplantation. Variation in the …

Complete primary structure of a human plasma membrane Ca2+ pump.

AK Verma, AG Filoteo, DR Stanford, ED Wieben… - Journal of Biological …, 1988 - Elsevier
cDNAs coding for a plasma membrane Ca2+ pump were isolated from a human teratoma
library and sequenced. The translated sequence contained 1,220 amino acids with a …

Human aromatase: gene resequencing and functional genomics

…, L Wang, BW Eckloff, D Schaid, ED Wieben… - Cancer research, 2005 - AACR
Aromatase [cytochrome P450 19 (CYP19)] is a critical enzyme for estrogen biosynthesis, and
aromatase inhibitors are of increasing importance in the treatment of breast cancer. We set …

[HTML][HTML] 3'tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer

…, TM Therneau, DI Smith, GA Poland, ED Wieben… - BMC genomics, 2009 - Springer
Background Massive parallel sequencing has the potential to replace microarrays as the
method for transcriptome profiling. Currently there are two protocols: full-length RNA …

SLC6A4 variation and citalopram response

…, JM Cunningham, ED Wieben… - American Journal of …, 2009 - Wiley Online Library
The influence of genetic variations in SLC6A4 (serotonin transporter gene) on citalopram
treatment of depression using the Sequenced Treatment to Relieve Depression (STAR*D) …

[HTML][HTML] Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling

RR McWilliams, ED Wieben, KG Rabe… - European Journal of …, 2011 - nature.com
Germline mutations in CDKN2A have been reported in pancreatic cancer families, but genetic
counseling for pancreatic cancer risk has been limited by lack of information on CDKN2A …