The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors
…, A Christopoulos, AP Davenport, E Kelly… - British journal of …, 2019 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …
[HTML][HTML] History of oncolytic viruses: genesis to genetic engineering
E Kelly, SJ Russell - Molecular therapy, 2007 - cell.com
Since the turn of the nineteenth century, when their existence was first recognized, viruses
have attracted considerable interest as possible agents of tumor destruction. Early case …
have attracted considerable interest as possible agents of tumor destruction. Early case …
Agonist‐selective mechanisms of GPCR desensitization
E Kelly, CP Bailey, G Henderson - British journal of …, 2008 - Wiley Online Library
The widely accepted model of G protein‐coupled receptor (GPCR) regulation describes a
system where the agonist‐activated receptors couple to G proteins to induce a cellular …
system where the agonist‐activated receptors couple to G proteins to induce a cellular …
An aged immune system drives senescence and ageing of solid organs
Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly 1 , 2 . To define the contribution of immune system ageing to organism …
mortality of the elderly 1 , 2 . To define the contribution of immune system ageing to organism …
[HTML][HTML] Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind …
Background Older adults (aged ≥70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …
death if they develop COVID-19 and are therefore a priority for immunisation should an …
[HTML][HTML] Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection
…, HE Humphries, B Jepson, EJ Kelly, E Plested… - Nature medicine, 2021 - nature.com
The global supply of COVID-19 vaccines remains limited. An understanding of the immune
response that is predictive of protection could facilitate rapid licensure of new vaccines. Data …
response that is predictive of protection could facilitate rapid licensure of new vaccines. Data …
[HTML][HTML] Efficacy of the ChAdOx1 nCoV-19 Covid-19 vaccine against the B. 1.351 variant
Background Assessment of the safety and efficacy of vaccines against the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is …
respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is …
[HTML][HTML] Intramuscular AZD7442 (tixagevimab–cilgavimab) for prevention of Covid-19
Background The monoclonal-antibody combination AZD7442 is composed of tixagevimab
and cilgavimab, two neutralizing antibodies against severe acute respiratory syndrome …
and cilgavimab, two neutralizing antibodies against severe acute respiratory syndrome …
[HTML][HTML] Phase 3 safety and efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 vaccine
Background The safety and efficacy of the AZD1222 (ChAdOx1 nCoV-19) vaccine in a large,
diverse population at increased risk for severe acute respiratory syndrome coronavirus 2 (…
diverse population at increased risk for severe acute respiratory syndrome coronavirus 2 (…
Best practices or best guesses? Assessing the efficacy of corporate affirmative action and diversity policies
Employers have experimented with three broad approaches to promoting diversity. Some
programs are designed to establish organizational responsibility for diversity, others to …
programs are designed to establish organizational responsibility for diversity, others to …