Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

…, A Copani, CJ Pike, ER Whittemore… - Proceedings of the …, 1993 - National Acad Sciences
The molecular mechanism responsible for the neurodegeneration in Alzheimer disease is
not known; however, accumulating evidence suggests that beta-amyloid peptide (A beta P) …

A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture

ER Whittemore, DT Loo, JA Watt, CW Cotmans - Neuroscience, 1995 - Elsevier
A variety of neurodegenerative disease states have been associated with oxidative damage
or stress. Such stress is thought to be mediated by excessive exposure of cells to reactive …

N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1 (2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with …

…, J Francis, J Limberis, S Malik, ER Whittemore… - … of Pharmacology and …, 2003 - ASPET
Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via
activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on …

Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

HJ Ng, ER Whittemore, MB Tran… - Proceedings of the …, 2007 - National Acad Sciences
Activation of brain α7 nicotinic acetylcholine receptors (α7 nAChRs) has broad therapeutic
potential in CNS diseases related to cognitive dysfunction, including Alzheimer's disease and …

Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons

ER Whittemore, DT Loo, CW Cotman - Neuroreport, 1994 - journals.lww.com
To investigate whether direct oxidative damage may induce neuronal death via an apoptotic
cell suicide pathway, we exposed cultured cortical neurons to the prooxidant hydrogen …

Differing effects ofN-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys

PJ Blanchet, S Konitsiotis, ER Whittemore… - … of Pharmacology and …, 1999 - ASPET
The antiparkinsonian and antidyskinetic profile of twoN-methyl-d-aspartate (NMDA) receptor
antagonists, a competitive antagonist, (R)-4-oxo-5-phosphononorvaline (MDL 100,453), …

Subtype-Selective N-Methyl-d-Aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Heteroarylalkynyl)-4-benzylpiperidines

…, SA Espitia, CS Konkoy, ER Whittemore… - Journal of medicinal …, 2000 - ACS Publications
4-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]phenol (8) and 4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]phenol
(9) are potent NR1a/2B receptor antagonists (IC 50 values 0.17 and 0.10 μM, …

Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.

ER Whittemore, W Yang, JA Drewe… - Molecular …, 1996 - ASPET
The human gamma-aminobutyric acidA (GABAA) receptor alpha 4 subunit was recently
cloned and characterized pharmacologically using radioligand binding techniques. These …

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.

VI Ilyin, ER Whittemore, J Guastella, E Weber… - Molecular …, 1996 - ASPET
Previous studies indicate that haloperidol, a therapeutically useful antipsychotic drug,
inhibits neuronal N-methyl-D-aspartate (NMDA) responses and has neuroprotective effects …

Antagonism of N-methyl-d-aspartate receptors by ς site ligands: Potency, subtype-selectivity and mechanisms of inhibition

ER Whittemore, VI Ilyin, RM Woodward - Journal of Pharmacology and …, 1997 - ASPET
Recent studies propose that ς site ligands antagonize N-methyl-d-aspartate (NMDA) receptors
by either direct, or indirect mechanisms of inhibition. To investigate this question further …