α-(N)-Heterocyclic carboxaldehyde thiosemicarbazones have been shown to be potent
inhibitors of the biosynthesis of DNA in mammalian cells. Studies with transplanted murine …

The effects of several nucleoside triphosphates as activators and inhibitors of the enzymic
reduction of ribonucleoside diphosphates to deoxynucleotides was studied. The enzyme was …

Methyl and benzo derivatives of 2-formylpyridine thiosemicarbazone were shown to be
potent inhibitors of the ribonucleoside diphosphate reductase of the Novikoff hepatoma. …

Inhibition by arabinonucleotides of the reduction of ribonucleotides to deoxyribonucleotides
with a partially purified enzyme system from rat tumor was studied. The di- and triphosphates …

Inhibition by hydroxyurea of partially purified ribonucleotide reductase from rat tumor was
studied in vitro. The inhibition was partially reversed by ferrous ions. At maximum iron …

Several analogs of 5-hydroxy-2-formylpyridine thiosemicarbazone (5-HP) that contain
isosteric replacement of sulfur by Se, NH or O have been synthesized. Measurement of the …

ADP ribonucleoside diphosphate of ara-CTP arabinosylcytosine triphosphate adenine BI, B2
subunits of E. coli ribonucleotide CDP ribonucleoside diphosphate of reductase cytosine MI…

The tumor-inhibitory agent 2-formylpyridine thiosemicarbazone (PT) and its 3- and 5-hydroxy
derivatives (3-HP and 5-HP) inhibited the incorporation of cytidine-5- 3 H into acid-soluble …

2-Formylpyridine thiosemicarbazone (PT), 3-hydroxy-2-formylpyridine thiosemicarbazone (3-HP),
and 5-hydroxy-2-formylpyridine thiosemicarbazone (5-HP) are potent inhibitors of the …

… The assay mixture was that described for crude extracts (Moore, 1967a), except that the …
(Moore, 1967a), except for variations in the incubation mixture. Several batches of enzyme were …