User profiles for E. M. BROWN

Eric M Brown

Broad Institute of MIT and Harvard
Verified email at broadinstitute.org
Cited by 5440

Extracellular calcium sensing and extracellular calcium signaling

EM Brown, RJ MacLeod - Physiological reviews, 2001 - journals.physiology.org
… Kifor, and EM Brown, unpublished data). Thus additional studies using similar approaches
will be important in other cell types expressing the CaR at higher levels in which it has been …

[HTML][HTML] The intestinal microbiome in early life: health and disease

…, LT Stiemsma, N Amenyogbe, EM Brown… - Frontiers in …, 2014 - frontiersin.org
Human microbial colonization begins at birth and continues to develop and modulate in
species abundance for about 3 years, until the microbiota becomes adult-like. During the same …

Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers

EM Brown - Physiological reviews, 1991 - journals.physiology.org
C. Mechanisms underlying modulation of parathyroid hormone secretion in response to
changes in extracellular calcium concentration persisting for hours to several days.............. D. …

Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

EM Brown, G Gamba, D Riccardi, M Lombardi… - Nature, 1993 - nature.com
MAINTENANCE of a stable internal environment within complex organisms requires specialized
cells that sense changes in the extracellular concentration of specific ions (such as Ca 2…

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

…, P Vassilev, X Li, AEH Elia, W Lu, EM Brown… - Nature …, 2003 - nature.com
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw (…

[HTML][HTML] Nomenclature of the proteins of cows' milk—Sixth revision

…, R Jimenez-Flores, GT Bleck, EM Brown… - Journal of dairy …, 2004 - Elsevier
This report of the American Dairy Science Association Committee on the Nomenclature,
Classification, and Methodology of Milk Proteins reviews changes in the nomenclature of milk …

[BOOK][B] Textbook of veterinary histology.

HD Dellmann, EM Brown - 1976 - cabdirect.org
A book in English on this subject is a rarity, and is very welcome, particularly at so
reasonable a price. There are seven contributors in addition to the two principal authors.

Mutations in the human Ca2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

MR Pollak, EM Brown, YHW Chou, SC Hebert, SJ Marx… - Cell, 1993 - cell.com
We demonstrate that mutations in the human Ca*+-sensing receptor gene cause familial
hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two …

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

…, MC Poznansky, CH Kos, MR Pollak, EM Brown… - Nature, 2006 - nature.com
During mammalian ontogeny, haematopoietic stem cells (HSCs) translocate from the fetal
liver to the bone marrow, where haematopoiesis occurs throughout adulthood 1 . Unique …

[HTML][HTML] Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut

…, SJ Weese, D Carter, MC Daigneault, EM Brown… - Microbiome, 2013 - Springer
Background Fecal bacteriotherapy (‘stool transplant’) can be effective in treating recurrent
Clostridium difficile infection, but concerns of donor infection transmission and patient …