Frozen shoulder
NL Millar, A Meakins, F Struyf, E Willmore… - Nature reviews Disease …, 2022 - nature.com
Frozen shoulder is a common debilitating disorder characterized by shoulder pain and
progressive loss of shoulder movement. Frozen shoulder is frequently associated with other …
progressive loss of shoulder movement. Frozen shoulder is frequently associated with other …
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
E Willmore, S de Caux, NJ Sunter, MJ Tilby… - Blood, 2004 - ashpublications.org
We report for the first time the use of a selective small-molecule inhibitor of DNA repair to
potentiate topoisomerase II (topo II) poisons, identifying DNA-dependent protein kinase (DNA-…
potentiate topoisomerase II (topo II) poisons, identifying DNA-dependent protein kinase (DNA-…
[HTML][HTML] Progressive exercise compared with best practice advice, with or without corticosteroid injection, for the treatment of patients with rotator cuff disorders …
…, M Bateman, A Hallett, H Thompson, E Willmore… - The Lancet, 2021 - thelancet.com
Background Corticosteroid injections and physiotherapy exercise programmes are commonly
used to treat rotator cuff disorders but the treatments' effectiveness is uncertain. We aimed …
used to treat rotator cuff disorders but the treatments' effectiveness is uncertain. We aimed …
Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualized and quantifiedin situ by a novel immunofluorescence …
E Willmore, AJ Frank, K Padget, MJ Tilby… - Molecular pharmacology, 1998 - ASPET
We have shown that both DNA topoisomerase (topo) IIα and β are in vivo targets for
etoposide using a new assay which directly measures topo IIα and β cleavable complexes in …
etoposide using a new assay which directly measures topo IIα and β cleavable complexes in …
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells
M López-Lázaro, E Willmore, CA Austin - Mutation Research/Genetic …, 2010 - Elsevier
DNA topoisomerases (topos) are the target of several drugs commonly used in cancer
chemotherapy; these drugs induce topo-DNA complexes with either topo I or topo II that …
chemotherapy; these drugs induce topo-DNA complexes with either topo I or topo II that …
[HTML][HTML] Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence
…, BE Gewurz, SJ Cockell, PS Jat, E Willmore… - PLoS …, 2014 - journals.plos.org
There are two major pathways leading to induction of NF-κB subunits. The classical (or
canonical) pathway typically leads to the induction of RelA or c-Rel containing complexes, and …
canonical) pathway typically leads to the induction of RelA or c-Rel containing complexes, and …
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia
E Willmore, SL Elliott, T Mainou-Fowler… - Clinical cancer …, 2008 - AACR
Purpose: del(17p), del(11q), and associated p53 dysfunction predict for short survival and
chemoresistance in B-cell chronic lymphocytic leukemia (CLL). DNA-dependent protein …
chemoresistance in B-cell chronic lymphocytic leukemia (CLL). DNA-dependent protein …
The novel poly (ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks
Poly(ADP-ribose) polymerase (PARP) inhibitors enhance DNA topoisomerase I (topo I)
poison-induced cytotoxicity and antitumor activity in vitro and in vivo, but the mechanism has not …
poison-induced cytotoxicity and antitumor activity in vitro and in vivo, but the mechanism has not …
[HTML][HTML] Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL
…, E Willmore, S Mackay, A Kater, E Eldering - Cell Death & …, 2021 - nature.com
… E–H CLL cells were nucleofected with NIK siRNA or control siRNA and cultured on 3T40L
… E In addition, cells were stained intracellularly for Bcl-XL and measured by flow cytometry. …
… E In addition, cells were stained intracellularly for Bcl-XL and measured by flow cytometry. …
Murine transgenic cells lacking DNA topoisomerase IIβ are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation
F Errington, E Willmore, MJ Tilby, L Li, G Li, W Li… - Molecular …, 1999 - ASPET
Murine transgenic cell lines lacking DNA topoisomerase II (topo II)β have been used to assess
the importance of topo IIβ as a drug target. Western blot analysis confirmed that the topo …
the importance of topo IIβ as a drug target. Western blot analysis confirmed that the topo …