Crystal structure of the human angiotensin-converting enzyme–lisinopril complex
R Natesh, SLU Schwager, ED Sturrock, KR Acharya - Nature, 2003 - nature.com
Angiotensin-converting enzyme (ACE) has a critical role in cardiovascular function by
cleaving the carboxy terminal His-Leu dipeptide from angiotensin I to produce a potent …
cleaving the carboxy terminal His-Leu dipeptide from angiotensin I to produce a potent …
[HTML][HTML] Ace revisited: a new target for structure-based drug design
KR Acharya, ED Sturrock, JF Riordan… - Nature Reviews Drug …, 2003 - nature.com
Current-generation angiotensin-converting enzyme (ACE) inhibitors are widely used for
cardiovascular diseases, including high blood pressure, heart failure, heart attack and kidney …
cardiovascular diseases, including high blood pressure, heart failure, heart attack and kidney …
Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure
…, C Llorens-Cortes, MR Ehlers, ED Sturrock - Pharmacological …, 2019 - ASPET
Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …
Structural Details on the Binding of Antihypertensive Drugs Captopril and Enalaprilat to Human Testicular Angiotensin I-Converting Enzyme,
R Natesh, SLU Schwager, HR Evans, ED Sturrock… - Biochemistry, 2004 - ACS Publications
Angiotensin converting enzyme (ACE) plays a critical role in the circulating or endocrine
renin−angiotensin system (RAS) as well as the local regulation that exists in tissues such as the …
renin−angiotensin system (RAS) as well as the local regulation that exists in tissues such as the …
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence
JL Guy, RM Jackson, KR Acharya, ED Sturrock… - Biochemistry, 2003 - ACS Publications
Angiotensin-converting enzyme 2 (ACE2), a homologue of ACE, represents a new and
potentially important target in cardio-renal disease. A model of the active site of ACE2, based on …
potentially important target in cardio-renal disease. A model of the active site of ACE2, based on …
The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - ASPET
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design
…, SLU Schwager, AT Nchinda, ED Sturrock… - Journal of molecular …, 2006 - Elsevier
Human somatic angiotensin I-converting enzyme (sACE) is a key regulator of blood pressure
and an important drug target for combating cardiovascular and renal disease. sACE …
and an important drug target for combating cardiovascular and renal disease. sACE …
[HTML][HTML] Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides
G Masuyer, SLU Schwager, ED Sturrock, RE Isaac… - Scientific reports, 2012 - nature.com
Angiotensin-I converting enzyme (ACE), a two-domain dipeptidylcarboxypeptidase, is a key
regulator of blood pressure as a result of its critical role in the renin-angiotensin-aldosterone …
regulator of blood pressure as a result of its critical role in the renin-angiotensin-aldosterone …
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV
…, D Oosthuizen, KR Acharya, ED Sturrock - Clinical …, 2020 - portlandpress.com
Angiotensin converting enzyme (ACE) is well-known for its role in blood pressure regulation
via the renin–angiotensin aldosterone system (RAAS) but also functions in fertility, immunity, …
via the renin–angiotensin aldosterone system (RAAS) but also functions in fertility, immunity, …
[HTML][HTML] The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific …
…, D Georgiadis, V Dive, KR Acharya, ED Sturrock - Journal of biological …, 2010 - ASBMB
Angiotensin-I-converting enzyme (ACE) plays a critical role in the regulation of blood pressure
through its central role in the renin-angiotensin and kallikrein-kinin systems. ACE contains …
through its central role in the renin-angiotensin and kallikrein-kinin systems. ACE contains …