Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis
than young. This may be due to accumulated cellular damage, decreases in adaptive …

Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and
improves metabolism and delays the onset of age-related diseases in mammals. Here we show …

Inflammation is a common component of acute injuries of the central nervous system (CNS)
such as ischemia, and degenerative disorders such as Alzheimer's disease. Glial cells play …

Type 2 diabetes is a chronic age-associated degenerative metabolic disease that reflects
relative insulin deficiency and resistance. Extracellular vesicles (EVs) (exosomes, …

Rationale: Multiple sclerosis (MS) and its mouse model, experimental autoimmune
encephalomyelitis (EAE), are inflammatory disorders of the central nervous system (CNS). The …

The potentially neurotrophic cytokine transforming growth factor‐β 1 (TGF‐β 1 ) is locally
expressed following human stroke and experimental ischemic lesions, but the cellular source(s) …

Aging is a major international concern that brings formidable socioeconomic and healthcare
challenges. Small molecules capable of improving the health of older individuals are being …

Recent evidence suggests that ovarian high‐grade serous carcinoma ( HGSC ) originates
from the epithelium of the fallopian tube. However, most mouse models are based on the …

Methamphetamine (METH) addiction is associated with several neuropsychiatric symptoms.
Little is known about the effects of METH on gene expression and epigenetic modifications …

Molecular analysis of brain tissue is greatly complicated by having many different classes of
neurons and glia interspersed throughout the brain. Fluorescence-activated cell sorting (…