Multinuclear platinum complexes represent a new class of anticancer agents, distinct in
terms of DNA binding features and the profile of antitumor activity from their mononuclear …

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that have been
implicated in various disease processes. Different classes of MMP inhibitors, including …

The ubiquitin−proteasome pathway plays a central role in regulation of the production and
destruction of cellular proteins. These pathways mediate proliferation and cell survival, …

A recent approach in anticancer chemotherapy envisages telomerase as a potentially useful
target. An attractive strategy deals with the development of compounds able to stabilize …

A series of DNA-intercalating potential antitumor agents, (amino)alkyl-substituted 2,3-dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-triones,
has been prepared by aminolysis of the …

A new approach to the synthesis of novel bifunctional dinuclear platinum complexes with
linear coordinating spermidine and spermine is reported. The synthetic pathway involves first …

The crude extract (80% MeOH in water) of Chelidonii herba exhibited very interesting cytotoxicity
against brine shrimp (Artemia salina Leach) nauplii and cultured human tumour cell in …

To enhance the outstanding biological response shown by the corresponding monomers 4
and 5, two classes of bis-acridine-4-carboxamides, 9, with a linker between the 4,4‘ positions, …

The synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones
(9-aza-APs) are described. The key intermediates in the synthesis are benz[g]…

The cytotoxic activity of mitoxantrone and related anthracenediones has been ascribed to
the ability of these cornpounds to interfere with DNA topoisomerase II function, result-ing in …