Pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta as regulators of angiogenesis and cancer

E Papadimitriou, E Pantazaka, P Castana… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Pleiotrophin (PTN) is a secreted heparin-binding growth factor that through its receptor
protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) has a significant regulatory effect on …

Chondroitin sulfate-cell membrane effectors as regulators of growth factor-mediated vascular and cancer cell migration

E Pantazaka, E Papadimitriou - … et Biophysica Acta (BBA)-General Subjects, 2014 - Elsevier
Background Glycosylation is a multi-step post-translational enzymatic process which
enhances the functional diversity of secreted or membrane proteins and is implicated in …

[HTML][HTML] Clinical relevance of mesenchymal-and stem-associated phenotypes in circulating tumor cells isolated from lung cancer patients

E Pantazaka, V Vardas, A Roumeliotou… - Cancers, 2021 - mdpi.com
Simple Summary Lung cancer is the most frequent malignancy in the world. Most lung
cancer patients are diagnosed at an advanced stage. To make matters worse, the survival of …

[HTML][HTML] Epithelial-to-mesenchymal transition of tumor cells: cancer progression and metastasis

V Vardas, E Politaki, E Pantazaka… - … International Journal of …, 2021 - ijdb.ehu.eus
Detection and characterization of circulating tumor cells (CTCs) with an epithelial-to-mesenchymal
transition (EMT) phenotype is very important, as it can contribute to the identification …

[HTML][HTML] Differential distribution, clustering, and lateral diffusion of subtypes of the inositol 1, 4, 5-trisphosphate receptor

E Pantazaka, CW Taylor - Journal of Biological Chemistry, 2011 - ASBMB
Regulation of inositol 1,4,5-trisphosphate (IP 3 ) receptors (IP 3 R) by IP 3 and Ca 2+ allows
them to initiate and regeneratively propagate intracellular Ca 2+ signals. The distribution …

[HTML][HTML] PD-L1/pS6 in circulating tumor cells (CTCs) during osimertinib treatment in patients with non-small cell lung cancer (NSCLC)

E Pantazaka, A Ntzifa, A Roumeliotou, E Lianidou… - Biomedicines, 2022 - mdpi.com
The PD-1/PD-L1 axis provides CTCs an escape route from the immune system.
Phosphorylation of the ribosomal protein S6 is implicated in the same pathway, following mTOR …

[HTML][HTML] Regulation of inositol 1, 4, 5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase

…, T Rahman, EJA Taylor, E Pantazaka… - Journal of biological …, 2010 - ASBMB
In HEK cells stably expressing type 1 receptors for parathyroid hormone (PTH), PTH causes
a sensitization of inositol 1,4,5-trisphosphate receptors (IP 3 R) to IP 3 that is entirely …

[HTML][HTML] Effect of osimertinib on CTCs and ctDNA in EGFR mutant non-small cell lung cancer patients: The prognostic relevance of liquid biopsy

…, N Jordana-Ariza, N Karachaliou, E Pantazaka… - Cancers, 2022 - mdpi.com
Simple Summary Osimertinib has become the standard of care for the first-line treatment of
EGFR-mutant NSCLC patients. The aim of this current translational research study was to …

Histone deacetylase‐based dual targeted inhibition in multiple myeloma

A Ferro, E Pantazaka… - Medicinal Research …, 2023 - Wiley Online Library
Despite enormous advances in terms of therapeutic strategies, multiple myeloma (MM) still
remains an incurable disease with MM patients often becoming resistant to standard …

[HTML][HTML] Phenotypic Characterization of Circulating Tumor Cells Isolated from Non-Small and Small Cell Lung Cancer Patients

A Roumeliotou, E Pantazaka, A Xagara… - Cancers, 2022 - mdpi.com
Simple Summary Studies have shown that JUNB and CXCR4 contribute to cell proliferation,
migration and invasion, hence claiming an important role in tumor progression and …