User profiles for Evgenii Chekalin

Evgenii Chekalin

Staff Bioinformatics Scientist
Verified email at illumina.com
Cited by 247

[HTML][HTML] Analysis of infected host gene expression reveals repurposed drug candidates and time-dependent host response dynamics for COVID-19

J Xing, R Shankar, A Drelich, S Paithankar, E Chekalin… - BioRxiv, 2020 - ncbi.nlm.nih.gov
The repurposing of existing drugs offers the potential to expedite therapeutic discovery against
the current COVID-19 pandemic caused by the SARS-CoV-2 virus. We have developed …

Ibrutinib blocks YAP1 activation and reverses BRAF inhibitor resistance in melanoma cells

SA Misek, PA Newbury, E Chekalin, S Paithankar… - Molecular …, 2022 - ASPET
Most B-Raf proto-oncogene (BRAF)–mutant melanoma tumors respond initially to BRAF
inhibitor (BRAFi)/mitogen-activated protein kinase kinase 1 inhibitor (MEKi) therapy, although …

Computational discovery of co-expressed antigens as dual targeting candidates for cancer therapy through bulk, single-cell, and spatial transcriptomics

E Chekalin, S Paithankar, R Shankar, J Xing, W Xu… - bioRxiv, 2023 - biorxiv.org
Bispecific antibodies (bsAbs) that bind to two distinct surface antigens on cancer cells are
emerging as an appealing therapeutic strategy in cancer immunotherapy. However, …

The impact of clinical genome sequencing in a global population of patients with suspected rare genetic disease

R Taft, E Thorpe, T Williams, C Shaw, E Chekalin… - 2023 - researchsquare.com
Clinical genome sequencing (cGS) holds promise as a unified diagnostic testing platform in
patients with a suspected rare genetic disease (RGD), however its performance and impact …

Direct observation of the generation of coherent optical phonons in thin antimony films by the femtosecond electron diffraction method

…, SA Aseev, AA Ishchenko, OV Misochko, SV Chekalin… - JETP letters, 2016 - Springer
The generation of coherent optical phonons in an antimony film has been directly observed
by the femtosecond electron diffraction method. The sample has been excited by a …

Detection of coherent optical phonons in a thin bismuth film by ultrafast electron diffraction

…, AA Ischenko, IV Kochikov, SV Chekalin… - Quantum …, 2020 - iopscience.iop.org
Coherent dynamics of lattice oscillations in a∼ 20-nm-thick film obtained by thermal sputtering
of bismuth is studied using ultrashort electron bunches synchronised with femtosecond …

Excitation and dissociation of molecules by femtosecond IR laser radiation in the gas phase and on dielectric surfaces

…, SV Pigul'skii, EA Ryabov, SV Chekalin - Quantum …, 2013 - iopscience.iop.org
This paper presents an overview of early studies and new experimental data on the effect of
near-IR ($0.8-1.8\\unicode {x3bc}\text {m} $) and mid-IR ($3.3-5.8\\unicode {x3bc}\text {m} $) …

Study of ultrafast processes in matter by means of time-resolved electron diffraction and microscopy

…, A Ischenko, O Misochko, S Chekalin… - EPJ Web of …, 2017 - epj-conferences.org
One of the most fundamental problems of modern natural science is the direct observation
of atomic motions in the course of various processes. For this purpose, in the experiment it is …

Ultrafast transmission electron microscope for studying the dynamics of the processes induced by femtosecond laser beams

…, BN Mironov, AA Timofeev, SV Chekalin… - Quantum …, 2017 - iopscience.iop.org
We have developed an ultrafast transmission electron microscope for studying dynamic
processes in samples excited by femtosecond laser pulses and for probing transient processes …

A study of ionisation of free and clustered molecules under the action of femtosecond laser radiation

…, DG Poydashev, EA Ryabov, SV Chekalin - Quantum …, 2014 - iopscience.iop.org
We have investigated the processes of excitation and ionisation of monomers and clusters
of ${\text {CF}} _ {3}{\text {I}},{\text {IF}} _ {2}{\text {CCOF}} $ and ${\text {Fe (CO)}} _ {5} $ …