The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells

…, JP Maffrand, G Le Fur, F Oury-Donat… - Molecular …, 2003 - ASPET
This study investigates the effects of SR141716, a selective CB 1 receptor antagonist that
reduces food intake and body weight of rodents, on Acrp30 mRNA expression in adipose tissue…

Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats

…, F Oury-Donat, JP Maffrand, B Scatton, F Lacheretz… - Hepatology, 2007 - journals.lww.com
This study investigated the effects of rimonabant (SR141716), an antagonist of the cannabinoid
receptor type 1 (CB1), on obesity-associated hepatic steatosis and related features of …

[HTML][HTML] SSR180711, a novel selective α7 nicotinic receptor partial agonist:(II) efficacy in experimental models predictive of activity against cognitive symptoms of …

…, R Steinberg, J Stemmelin, F Oury-Donat… - …, 2007 - nature.com
… During this recall session, the objects A and B were placed in the open field, and the time
that animal took to explore the familiar object A (F) and the novel object B (N) were recorded. A …

Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist

D Gully, B Labeeuw, R Boigegrain, F Oury-Donat… - … of Pharmacology and …, 1997 - ASPET
… The HT 29 cell line (obtained from the American Type Culture Collection, Rockville, MD)
was cultured under similar conditions in Dulbecco’s modified Eagle’s medium/F-12 medium …

[HTML][HTML] Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of …

…, R Alonso, P Avenet, F Oury-Donat… - …, 2005 - nature.com
… Administration of SSR504734 (10 mg/kg ip) produced a rapid and sustained increase in
PFC extracellular levels of glycine (F(1,16)=10.23, P<0.01 and F(12,192)=8.03, P<0.001 for the …

[HTML][HTML] SSR180711, a novel selective α7 nicotinic receptor partial agonist:(1) binding and functional profile

…, R Steinberg, G Griebel, F Oury-Donat… - …, 2007 - nature.com
In this paper, we report on the pharmacological and functional profile of SSR180711 (1, 4-Diazabicyclo
[3.2. 2] nonane-4-carboxylic acid, 4-bromophenyl ester), a new selective α7 …

The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 …

…, G Elachouri, B Scatton, G Le Fur, F Oury-Donat… - Molecular …, 2006 - ASPET
Adipocyte cell proliferation is an important process in body fat mass development in obesity.
Adiponectin or Acrp30 is an adipocytokine exclusively expressed and secreted by adipose …

Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells

N Vita, F Oury-Donat, P Chalon, M Guillemot… - European journal of …, 1998 - Elsevier
The human levocabastine-sensitive neurotensin NT 2 receptor was cloned from a cortex
cDNA library and stably expressed in Chinese hamster ovary (CHO) cells in order to study its …

Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia

…, B Biton, R Steinberg, M Sevrin, F Oury-Donat… - Pharmacology …, 2008 - Elsevier
On native human, rat and mouse glycine transporter-1(GlyT1), SSR130800 behaves as a
selective inhibitor with IC50 values of 1.9, 5.3 and 6.8 nM, respectively. It reversibly blocked …

Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant …

…, M Didier, P Avenet, G Le Fur, F Oury-Donat… - Neuroscience, 2008 - Elsevier
SR58611A is a selective β 3 -adrenoceptor (Adrb3) agonist which has demonstrated
antidepressant and anxiolytic properties in rodents. The present study confirmed the detection of …