Proof-of-concept trial of an α7 nicotinic agonist in schizophrenia

…, JO Stevens, L Martin, LE Adler, F Soti… - Archives of general …, 2006 - jamanetwork.com
Context The α7 nicotinic acetylcholine receptor gene,CHRNA7, is associated with genetic
transmission of schizophrenia and related cognitive and neurophysiological sensory gating …

Initial phase 2 trial of a nicotinic agonist in schizophrenia

…, BD Wagner, GO Zerbe, F Soti… - American Journal of …, 2008 - Am Psychiatric Assoc
Objective: Nicotinic acetylcholine receptors are possible therapeutic targets for schizophrenia,
as shown by neurobiological and molecular evidence for deficiencies in expression of α 7 …

[HTML][HTML] The nemertine toxin anabaseine and its derivative DMXBA (GTS-21): Chemical and pharmacological properties

W Kem, F Soti, K Wildeboer, S LeFrancois… - Marine Drugs, 2006 - mdpi.com
Nemertines are a phylum of carnivorous marine worms that possess a variety of alkaloidal,
peptidic or proteinaceous toxins that serve as chemical defenses against potential predators. …

Activation and desensitization of nicotinic α7-type acetylcholine receptors by benzylidene anabaseines and nicotine

RL Papke, WR Kem, F Soti… - … of Pharmacology and …, 2009 - ASPET
Nicotinic receptor activation is inextricably linked to desensitization. This duality affects our
ability to develop useful therapeutics targeting nicotinic acetylcholine receptor (nAChR). …

Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia

…, S Shatti, A Olincy, L Johnson, LF Martin, F Soti… - Biological …, 2011 - Elsevier
BACKGROUND:: 3-(2,4-dimethoxybenzylidene)-anabaseine (DMXB-A) is a partial agonist
at α7 nicotinic acetylcholine receptors that has been evaluated clinically for treatment of …

Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2, 4-dimethoxy) benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions …

…, K Prokai-Tatrai, J Porter-Papke, F Soti - Molecular …, 2004 - ASPET
3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride (DMXBA; GTS-21), an
Alzheimer's drug candidate, selectively stimulates α7 nicotinic acetylcholine receptors. It rapidly …

Stable free radicals. Part I. A new principle governing the stability of organic free radicals

…, P Hudson, AR Katritzky, F Soti - Journal of the Chemical …, 1974 - pubs.rsc.org
The concept of merostabilisation, the stabilisation of free radicals by simultaneous conjugation
with electron donor and acceptor groups, is developed by valence bond, MO, and Linnett …

Relative toxicities and neuromuscular nicotinic receptor agonistic potencies of anabasine enantiomers and anabaseine

…, DR Gardner, RJ Molyneux, CWT Chang, F Soti… - Neurotoxicology and …, 2006 - Elsevier
Anabasine occurring in wild tree tobacco (Nicotiana glauca) and anabaseine occurring in
certain animal venoms are nicotinic receptor agonist toxins. Anabasine lacks the imine double …

[HTML][HTML] Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia

…, S Shatti, LF Martin, D Singel, YP Du, F Soti… - …, 2010 - nature.com
3-(2, 4-Dimethoxybenzylidene)-anabaseine (DMXB-A) is a partial agonist at α7-nicotinic
acetylcholine receptors and is now in early clinical development for treatment of deficits in …

Positive modulation of α7 nAChR responses in rat hippocampal interneurons to full agonists and the α7-selective partial agonists, 4OH-GTS-21 and S 24795

…, P Morain, C Trocme-Thibierge, WR Kem, F Soti… - …, 2009 - Elsevier
One approach for the identification of therapeutic agents for Alzheimer's disease has
focused on the research of α7 nAChR-selective agonists such as the partial agonists 3-(4-hydroxy,2…