5-hydroxytryptamine receptors in the human cardiovascular system
AJ Kaumann, FO Levy - Pharmacology & therapeutics, 2006 - Elsevier
The human cardiovascular system is exposed to plasma 5-hydroxytryptamine (5-HT, serotonin),
usually released from platelets. 5-HT can produce harmful acute and chronic effects. …
usually released from platelets. 5-HT can produce harmful acute and chronic effects. …
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
…, V Sundvold, M Saxena, FO Levy… - The Journal of …, 2001 - rupress.org
In T cells, cAMP-dependent protein kinase (PKA) type I colocalizes with the T cell receptor–CD3
complex (TCR/CD3) and inhibits T cell function via a previously unknown proximal target…
complex (TCR/CD3) and inhibits T cell function via a previously unknown proximal target…
Structure, function, and regulation of human cAMP-dependent protein kinases.
…, R Solberg, HK Knutsen, FO Levy… - Advances in second …, 1997 - europepmc.org
A large number of hormones, neurotransmitters, and other signaling substances that bind to
G-protein-coupled cell-surface receptors have their signals converge at one sole second …
G-protein-coupled cell-surface receptors have their signals converge at one sole second …
International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
…, E Lacivita, EK Lambe, M Leopoldo, FO Levy… - Pharmacological …, 2021 - ASPET
5-HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …
and various drugs in development. Their diversity of structure and function reflects the …
The serotonin 5-HT7 receptors: two decades of research
…, KW Andressen, G Haegeman, FO Levy… - Experimental brain …, 2013 - Springer
Like most neurotransmitters, serotonin possesses a simple structure. However, the
pharmacological consequences are more complex and diverse. Serotonin is involved in numerous …
pharmacological consequences are more complex and diverse. Serotonin is involved in numerous …
[HTML][HTML] Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies
T Brattelid, LH Winer, FO Levy, K Liestøl… - BMC molecular …, 2010 - Springer
Background Quantitative real-time RT-PCR (RT-qPCR) is a highly sensitive method for
mRNA quantification, but requires invariant expression of the chosen reference gene(s). In …
mRNA quantification, but requires invariant expression of the chosen reference gene(s). In …
[HTML][HTML] Ras-dependent ERK activation by the human Gs-coupled serotonin receptors 5-HT4 (b) and 5-HT7 (a)
JH Norum, K Hart, FO Levy - Journal of Biological Chemistry, 2003 - ASBMB
Receptor tyrosine kinases activate mitogen-activated protein (MAP) kinases through Ras,
Raf-1, and MEK. Receptor tyrosine kinases can be transactivated by G protein-coupled …
Raf-1, and MEK. Receptor tyrosine kinases can be transactivated by G protein-coupled …
Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action
…, S Guccione, LR Moltzau, FO Levy… - Journal of medicinal …, 2011 - ACS Publications
We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c,
and 9e with affinity values toward 5-HT 7 R and 5-HTT were selected to probe their …
and 9e with affinity values toward 5-HT 7 R and 5-HTT were selected to probe their …
NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors
Small molecules interfering with Rac1 activation are considered as potential drugs and are
already studied in animal models. A widely used inhibitor without reported attenuation of …
already studied in animal models. A widely used inhibitor without reported attenuation of …
The human 5‐HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects
KA Krobert, FO Levy - British journal of pharmacology, 2002 - Wiley Online Library
Using membranes from stably or transiently transfected HEK293 cells cultured in 5‐HT‐free
medium and expressing the recombinant human 5‐HT 7 receptor splice variants (h5‐HT 7(a…
medium and expressing the recombinant human 5‐HT 7 receptor splice variants (h5‐HT 7(a…