M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease

…, S Bonnafous, A Louvet, F Lafdil, F Pecker… - Hepatology, 2014 - journals.lww.com
Alcoholic and nonalcoholic fatty liver disease (ALD and NAFLD) are the predominant
causes of liver-related mortality in Western countries. We have shown that limiting classical (M1) …

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

…, V Deveaux, C Pavoine, A Zimmer, F Pecker… - Hepatology, 2011 - journals.lww.com
Activation of Kupffer cells plays a central role in the pathogenesis of alcoholic liver disease.
Because cannabinoid CB2 receptors (CB2) display potent anti-inflammatory properties, we …

Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology

C Pavoine, F Pecker - Cardiovascular research, 2009 - academic.oup.com
Sphingomyelinases (SMases) hydrolyse sphingomyelin, releasing ceramide and creating a
cascade of bioactive lipids. These lipids include sphingosine and sphingosine-1-phosphate, …

Dedifferentiation of atrial myocytes during atrial fibrillation: role of fibroblast proliferation in vitro

C Rücker-Martin, F Pecker, D Godreau… - Cardiovascular …, 2002 - academic.oup.com
Objectives: Severe myocyte alterations, characterized by enlarged myocytes and myolysis,
is observed in fibrillating and dilated atria and contributes to atrial fibrillation. The aim of this …

[HTML][HTML] Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities

…, JL Dubois-Randé, L Hittinger, C Pavoine, F Pecker - PloS one, 2009 - journals.plos.org
Background The tripeptide glutathione (L-gamma-glutamyl-cysteinyl-glycine) is essential to
cell survival, and deficiency in cardiac and systemic glutathione relates to heart failure …

Glucagon stimulates the cardiac Ca2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase

PF Méry, V Brechler, C Pavoine, F Pecker… - Nature, 1990 - nature.com
GLUCAGON exerts positive inotropic and chronotropic effects in the heart 1,2 . Like its
glycogenolytic effect in liver cells 3 , the cardiac effects of glucagon are often correlated with …

[HTML][HTML] TNFR1 and TNFR2 signaling interplay in cardiac myocytes

N Defer, A Azroyan, F Pecker, C Pavoine - Journal of biological chemistry, 2007 - ASBMB
Tumor necrosis factor α (TNFα) plays a major role in chronic heart failure, signaling through
two different receptor subtypes, TNFR1 and TNFR2. Our aim was to further delineate the …

Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats

…, T Levade, C Thuillez, L Hittinger, F Pecker - Journal of molecular and …, 2007 - Elsevier
Deficiency in cellular thiol tripeptide glutathione (l-γ glutamyl–cysteinyl–glycine) determines
the severity of several chronic and inflammatory human diseases that may be relieved by …

N-Acetylcysteine Treatment Normalizes Serum Tumor Necrosis Factor-α Level and Hinders the Progression of Cardiac Injury in Hypertensive Rats

…, JL Dubois-Rande, L Hittinger, F Pecker - Circulation, 2004 - Am Heart Assoc
Background— Studies in isolated cardiomyocytes showed that replenishment in cellular
glutathione, achieved with the glutathione precursor N-acetylcysteine (NAC), abrogated …

N-Acetylcysteine Prevents the Deleterious Effect of Tumor Necrosis Factor-α on Calcium Transients and Contraction in Adult Rat Cardiomyocytes

…, M Best-Belpomme, T Levade, C Pavoine, F Pecker - Circulation, 2004 - Am Heart Assoc
Background— The negative effect of tumor necrosis factor-α (TNF-α) on heart contraction,
which is mediated by sphingosine, is a major component in heart failure. Because the cellular …