The “receiver operating characteristic” (ROC) curve method is a well-recognized metric
used as an objective way to evaluate the ability of a given test to discriminate between two …

The metabotropic glutamate receptors are G-protein coupled receptors (GPCR) involved in
the regulation of many synapses, including most glutamatergic fast excitatory synapses. Eight …

The γ-aminobutyric acid, type B (GABA B ) receptor is well recognized as being composed
of two subunits, GABA B1 and GABA B2 . Both subunits share structural homology with other …

Although agonists bind directly in the heptahelical domain (HD) of most class-I rhodopsin-like
G protein coupled receptors (GPCRs), class-III agonists bind in the extracellular domain of …

Developing nondopaminergic palliative treatments for Parkinson's disease represents a
major challenge to avoid the debilitating side effects produced by l‐DOPA therapy. Increasing …

In a previous study we reported that the addition of a carboxylic group to the mGlu receptor
agonist aminocyclopentane-1,3-dicarboxylate (ACPD) changes its properties from agonist to …

Glutamate plays a key role in modulation of nociceptive processing. This excitatory amino
acid exerts its action through two distinct types of receptors, ionotropic and metabotropic …

The recent discovery of positive allosteric modulators (PAMs) for G-protein-coupled receptors
open new possibilities to control a number of physiological and pathological processes. …

The metabotropic glutamate receptors are GTP-binding-protein (G-protein) coupled receptors
that play important roles in regulating the activity of many synapses in the central nervous …

Metabotropic glutamate (mGlu) receptors are promising targets to treat numerous brain
disorders. So far, allosteric modulators are the only subtype selective ligands, but pure agonists …