User profiles for Frank A. Middleton

Frank Middleton

Professor of Neuroscience, Upstate Medical University
Verified email at upstate.edu
Cited by 29223

Basal ganglia and cerebellar loops: motor and cognitive circuits

FA Middleton, PL Strick - Brain research reviews, 2000 - Elsevier
The traditional view that the basal ganglia and cerebellum are simply involved in the control
of movement has been challenged in recent years. One of the pivotal reasons for this …

Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function

FA Middleton, PL Strick - Science, 1994 - science.org
The possibility that neurons in the basal ganglia and cerebellum innervate areas of the
cerebral cortex that are involved in cognitive function has been a controversial subject. Here, …

Cerebellar projections to the prefrontal cortex of the primate

FA Middleton, PL Strick - Journal of neuroscience, 2001 - Soc Neuroscience
The cerebellum is known to project via the thalamus to multiple motor areas of the cerebral
cortex. In this study, we examined the extent and anatomical organization of cerebellar input …

[HTML][HTML] Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

K Mirnics, FA Middleton, A Marquez, DA Lewis, P Levitt - Neuron, 2000 - cell.com
Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and
control subjects and hierarchical data analysis revealed that transcripts encoding proteins …

PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

…, TG Beach, MB Graeber, FA Middleton… - Science translational …, 2010 - science.org
Parkinson’s disease affects 5 million people worldwide, but the molecular mechanisms
underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis of …

Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies

FA Middleton, PL Strick - Brain and cognition, 2000 - Elsevier
The traditional view that the basal ganglia are simply involved in the control of movement
has been challenged in recent years. Three lines of evidence indicate that the basal ganglia …

Basal-ganglia 'projections' to the prefrontal cortex of the primate

FA Middleton, PL Strick - Cerebral cortex, 2002 - academic.oup.com
We used retrograde transneuronal transport of the McIntyre-B strain of herpes simplex virus
type 1 to examine the extent and organization of basal-ganglia–thalamocortical projections …

Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia

FA Middleton, K Mirnics, JN Pierri… - Journal of …, 2002 - Soc Neuroscience
Dysfunction of the dorsal prefrontal cortex (PFC) in schizophrenia may be associated with
alterations in the regulation of brain metabolism. To determine whether abnormal expression …

Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse

K Mirnics, FA Middleton, DA Lewis, P Levitt - Trends in neurosciences, 2001 - cell.com
The level of cellular and molecular complexity of the nervous system creates unique problems
for the neuroscientist in the design and implementation of functional genomic studies. …

Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder

…, RM Chiavacci, T Sakurai, C Rabin, FA Middleton… - Nature …, 2012 - nature.com
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric
disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) …