Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of …

…, FP Guengerich, FF Kadlubar - Proceedings of the …, 1989 - National Acad Sciences
Aromatic amines are well known as occupational carcinogens and are found in cooked
foods, tobacco smoke, synthetic fuels, and agricultural chemicals. For the primary arylamines, …

Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal …

…, RC Stotts, M Hauer-Jensen, FF Kadlubar - … , biomarkers & prevention …, 1994 - AACR
The metabolic activation of food-borne heterocyclic amines to colon carcinogens in humans
is hypothesized to occur via N-oxidation followed by O-acetylation to form the N-acetoxy …

Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

…, NP Lang, MA Butler, CH Teitel, FF Kadlubar - …, 1991 - academic.oup.com
The metabolic activation of the food-borne rodent carcinogens 2-amino-3-methylimidazo [4,5-f]quinoline
(IQ), 2-amino-3,8-dimethylimidazo [4,5-f]quinoline (MeIQx), 2-amino-1-methyl-6-…

Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients

…, C Sweeney, SL MacLeod, FF Kadlubar… - Breast cancer research …, 2005 - Springer
Tamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We
sought to determine if genetic variability in the tamoxifen metabolic pathway influenced overall …

Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer

…, Y Guo, X Zhang, Y Shen, B Qiang, FF Kadlubar… - Gastroenterology, 2005 - Elsevier
Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in many
steps of cancer development. Single nucleotide polymorphisms (SNPs) in the COX-2 promoter …

p53 genotypes and haplotypes associated with lung cancer susceptibility and ethnicity

…, N Makan, WK Hong, FF Kadlubar… - Journal of the …, 2002 - academic.oup.com
Background: The p53 tumor suppressor protein is important in cell-cycle control, apoptosis,
and DNA repair. Mutations in p53 have been associated with inherited cancer susceptibility. …

Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression

…, B Green, NP Lang, FF Kadlubar - Pharmacogenetics …, 2001 - journals.lww.com
The patterns of expression of glutathione S-transferases A1 and A2 in human liver (hGSTA1
and hGSTA2, respectively) are highly variable, notably in the ratio of hGSTA1/hGSTA2. We …

Detoxification of electrophilic compounds by glutathione S‐transferase catalysis: Determinants of individual response to chemical carcinogens and chemotherapeutic …

BF Coles, FF Kadlubar - Biofactors, 2003 - Wiley Online Library
The glutathione S‐transferases (GSTs) catalyze the GSH‐dependent detoxification of reactive
electrophiles such as genotoxic chemical carcinogens and cytotoxic chemotherapeutic …

The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer.

…, JB Taylor, NP Lang, FF Kadlubar - Environmental …, 1992 - ehp.niehs.nih.gov
Cytosolic glutathione S-transferases (GSTs) are a supergene family of dimeric enzymes
capable of detoxifying a number of carcinogenic electrophiles. Of the numerous components of …

Hepatic Microsomal N-Glucuronidation and Nucleic Acid Binding of N-Hydroxy Arylamines in Relation to Urinary Bladder Carcinogenesis

FF Kadlubar, JA Miller, EC Miller - Cancer research, 1977 - AACR
Uridine 5′-diphosphoglucuronic acid-fortified hepatic microsomes from dogs, rats, or
humans rapidly metabolized [ 3 H]-N-hydroxy-2-naphthylamine (N-HO-2-NA) to a water-soluble …