The ability of our cells to maintain genomic integrity is fundamental for protection from cancer
development. Central to this process is the ability of cells to recognize and repair DNA …

MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult
tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. The …

Recruitment of DNA repair factors and modulation of chromatin structure at sites of DNA
double-strand breaks (DSBs) is a complex and highly orchestrated process. We developed a …

The mechanisms by which DNA-damaging agents trigger the induction of the stress response
protein p53 are poorly understood but may involve alterations of chromatin structure or …

Psoralen plus UVA light (PUVA) is commonly used to treat psoriasis, a common skin disorder
associated with rapid proliferation of cells. PUVA exerts its antiproliferative activity through …

Lysine acetyltransferases (KATs) are a family of epigenetic enzymes involved in the
regulation of gene expression; they represent a promising class of emerging drug targets. The …

Background The evolutionary conserved cyclin-dependent kinase phosphatase hCdc14A
has been shown to play potential roles in the regulation of mitotic exit and in the centrosome …

Interference with transcription triggers a stress response leading to the induction of the
tumour suppressor p53. If transcription is not restored within a certain time frame cells may …

Regulation of epidermal growth factor receptor (EGFR) signaling requires the concerted
action of both positive and negative factors. While the existence of numerous molecules that …

The paralogous histone acetyltransferases EP300 and CREBBP are two of the master regulators
of transcription by controlling both enhancer and promoter activity through histone and …