The aryl hydrocarbon receptor antagonist, 3′ methoxy-4′ nitroflavone, attenuates 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor …
JW Davis II, AD Burdick, FT Lauer… - Toxicology and applied …, 2003 - Elsevier
Previous studies have demonstrated that 2,3,7,8 tetracholorodibenzo-p-dioxin (TCDD)
mimics epidermal growth factor receptor (EGFR) signaling in the MCF-10A human mammary …
mimics epidermal growth factor receptor (EGFR) signaling in the MCF-10A human mammary …
Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1
A León-Buitimea, L Rodríguez-Fragoso, FT Lauer… - Toxicology letters, 2012 - Elsevier
Breast cancer is the most common cancer and the second leading cause of cancer-related
mortality worldwide. The etiology of breast cancer is very diverse and ethanol (EtOH) …
mortality worldwide. The etiology of breast cancer is very diverse and ethanol (EtOH) …
Cytochrome P450 1B1 is required for 7, 12-dimethylbenz (a)-anthracene (DMBA) induced spleen cell immunotoxicity
J Gao, FT Lauer, S Dunaway… - Toxicological …, 2005 - academic.oup.com
7,12-Dimethylbenz(a)anthracene (DMBA) is a potent carcinogen that induces immunosuppression
of both humoral and cell-mediated immunity in mice and other species. Previous …
of both humoral and cell-mediated immunity in mice and other species. Previous …
Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice
S Medina, FT Lauer, EF Castillo, AM Bolt… - Toxicology and applied …, 2020 - Elsevier
Human exposures to environmental metals, including uranium (U) and arsenic (As) are a
global public health concern. Chronic exposures to U and As are linked to many adverse …
global public health concern. Chronic exposures to U and As are linked to many adverse …
Activation of dioxin response element (DRE)-associated genes by benzo (a) pyrene 3, 6-quinone and benzo (a) pyrene 1, 6-quinone in MCF-10A human mammary …
SW Burchiel, TA Thompson, FT Lauer… - Toxicology and applied …, 2007 - Elsevier
Benzo(a)pyrene (BaP) is a known human carcinogen and a suspected breast cancer
complete carcinogen. BaP is metabolized by several metabolic pathways, some having …
complete carcinogen. BaP is metabolized by several metabolic pathways, some having …
Low-dose synergistic immunosuppression of T-dependent antibody responses by polycyclic aromatic hydrocarbons and arsenic in C57BL/6J murine spleen cells
Q Li, FT Lauer, KJ Liu, LG Hudson… - Toxicology and applied …, 2010 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) and arsenic are both environmental agents that
are known to have significant immunotoxicity. Previous studies have shown that PAH …
are known to have significant immunotoxicity. Previous studies have shown that PAH …
Immunotoxicity and biodistribution analysis of arsenic trioxide in C57Bl/6 mice following a 2-week inhalation exposure
SW Burchiel, LA Mitchell, FT Lauer, X Sun… - Toxicology and applied …, 2009 - Elsevier
In these studies the immunotoxicity of arsenic trioxide (ATO, As 2 O 3 ) was evaluated in mice
following 14 days of inhalation exposures (nose only, 3 h per day) at concentrations of 50 …
following 14 days of inhalation exposures (nose only, 3 h per day) at concentrations of 50 …
[HTML][HTML] Differential susceptibility of human peripheral blood T cells to suppression by environmental levels of sodium arsenite and monomethylarsonous acid
SW Burchiel, FT Lauer, EJ Beswick, AJ Gandolfi… - PloS one, 2014 - journals.plos.org
Human exposure to arsenic in drinking water is known to contribute to many different health
outcomes such as cancer, diabetes, and cardiopulmonary disease. Several epidemiological …
outcomes such as cancer, diabetes, and cardiopulmonary disease. Several epidemiological …
[HTML][HTML] Inhibition of red blood cell development by arsenic-induced disruption of GATA-1
…, AM Bolt, H Zhang, G Wan, H Xu, FT Lauer… - Scientific Reports, 2020 - nature.com
Anemia is a hematological disorder that adversely affects the health of millions of people
worldwide. Although many variables influence the development and exacerbation of anemia, …
worldwide. Although many variables influence the development and exacerbation of anemia, …
Uptake and toxicity of respirable carbon-rich uranium-bearing particles: Insights into the role of particulates in uranium toxicity
…, A Brearley, M Spilde, T Howard, FT Lauer… - … science & technology, 2021 - ACS Publications
Particulate matter (PM) presents an environmental health risk for communities residing
close to uranium (U) mine sites. However, the role of the particulate form of U on its cellular …
close to uranium (U) mine sites. However, the role of the particulate form of U on its cellular …