User profiles for G Dubyak
George DubyakProfessor of Physiology & Biophysics, Case Western Reserve University Verified email at case.edu Cited by 24061 |
Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides
GR Dubyak, C El-Moatassim - American Journal of …, 1993 - journals.physiology.org
… The functionally identified nucleotide or P2-purinergic receptors include 1) ATP receptors
that stimulate G protein-coupled effector enzymes and signaling cascades, including inositol …
that stimulate G protein-coupled effector enzymes and signaling cascades, including inositol …
[HTML][HTML] Towards a revised nomenclature for P1 and P2 receptors
…, MP Abbracchio, G Burnstock, GR Dubyak… - Trends in …, 1997 - ncbi.nlm.nih.gov
… Dubyak 4 summarized the evidence that ATP worked through two different transduction
mechanisms: intrinsic ion channels and G … classified in two families: G protein-coupled receptors …
mechanisms: intrinsic ion channels and G … classified in two families: G protein-coupled receptors …
P2X7 receptor regulation of non‐classical secretion from immune effector cells
GR Dubyak - Cellular microbiology, 2012 - Wiley Online Library
… IL ‐1β (and IL ‐18) lacks a signal sequence for compartmentation within the G olgi and
classical secretory vesicles and the proIL‐1β precursor accumulates within the cytosol following …
classical secretory vesicles and the proIL‐1β precursor accumulates within the cytosol following …
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.
BCL-2 is a 26-kDa integral membrane protein that represses apoptosis by an unknown
mechanism. Recent findings indicate that Ca2+ release from the endoplasmic reticulum (ER) …
mechanism. Recent findings indicate that Ca2+ release from the endoplasmic reticulum (ER) …
[PDF][PDF] Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells
…, F An, PN Lalli, N Muqim, VS Shapiro, GR Dubyak… - Immunity, 2008 - cell.com
Costimulatory signals are critical to T cell activation, but how their effects are mediated
remains incompletely characterized. Here, we demonstrate that locally produced C5a and C3a …
remains incompletely characterized. Here, we demonstrate that locally produced C5a and C3a …
Nonclassical IL-1β secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages
… For processing of extracellular medium, the collected 1-ml samples were centrifuged at
10,000 × g for 10 s to remove any detached cells, followed by transfer of the supernatant to a …
10,000 × g for 10 s to remove any detached cells, followed by transfer of the supernatant to a …
[HTML][HTML] N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
… at 720 g, 10k g and 100k g to obtain distinct subcellular fractions. … g and 10,000 g to remove
nuclei and larger organelles, respectively. The supernatant was then centrifuged at 16,000 g …
nuclei and larger organelles, respectively. The supernatant was then centrifuged at 16,000 g …
[HTML][HTML] Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays an important role in host
defense and inflammatory diseases. The maturation and secretion of IL-1β are mediated by …
defense and inflammatory diseases. The maturation and secretion of IL-1β are mediated by …
Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release
JM Kahlenberg, GR Dubyak - American Journal of …, 2004 - journals.physiology.org
… The cells were then pelleted at 300 g for 30 s, and all but ∼50 μl of the buffer was removed.
The … Lysates were spun at 15,000 g for 15 min, and the supernatant was transferred to a new …
The … Lysates were spun at 15,000 g for 15 min, and the supernatant was transferred to a new …
Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation
…, LL Gilmour, S Louie, JE Cupp, GR Dubyak… - The Journal of …, 2011 - journals.aai.org
… Culture supernatants were collected by centrifugation twice at 500 × g for 5 min. Transwell
migration assays were performed with 500 μl apoptotic cell supernatant in the lower chamber …
migration assays were performed with 500 μl apoptotic cell supernatant in the lower chamber …