The UDP glucuronosyltransferase gene super family: suggested nomenclature based on evolutionary divergence

…, T Iyanagi, PL Jansen, D Lancet, GJ Mulder… - DNA and cell …, 1991 - liebertpub.com
A nomenclature system for the UDP glucuronosyltransferase superfamily is proposed, based
on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species …

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

…, F Bernaudin, R Girot, R Dorazio, GJ Mulder… - Nature, 2010 - nature.com
The β-haemoglobinopathies are the most prevalent inherited disorders worldwide. Gene
therapy of β-thalassaemia is particularly challenging given the requirement for massive …

Glucuronidation and its role in regulation of biological activity of drugs

GJ Mulder - Annual review of pharmacology and toxicology, 1992 - annualreviews.org
Glucuronidation is a major drug-metabolizing reaction. It involves the trans fer of the glucuronic
acid group from UDP-glucuronic acid (UDPGlucA) to an acceptor group on a substrate. …

Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain

…, B Van De Water, E De Heer, GJ Mulder… - … of Pharmacology and …, 1997 - ASPET
Cisplatin-induced nephrotoxicity was studied in porcine proximal tubular cells, focusing on
the relationship between mitochondrial damage, reactive oxygen species (ROS) and cell …

Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N, O-sulfonation in chemical carcinogenesis of aromatic …

GJ Mulder, JH Meerman - Environmental health perspectives, 1983 - ehp.niehs.nih.gov
Mulder, GJ Generation of reactive intermediates from xenobiotics by sulfate conjugation;
their potential role in chemical carcinogenesis. In: Sulfation of Drugs and Related Compounds (…

Effect of recombinant human pentraxin 2 vs placebo on change in forced vital capacity in patients with idiopathic pulmonary fibrosis: a randomized clinical trial

…, KC Meyer, M Kreuter, H Santin-Janin, GJ Mulder… - Jama, 2018 - jamanetwork.com
… Dr Mulder reports being a nonexecutive director on the board of Promedior. Dr Bartholmai
reports receipt of personal fees from Promedior for serving as a scientific advisor during the …

Sulfation

GJ Mulder, WB Jakoby - Conjugation reactions in drug …, 1990 - taylorfrancis.com
Sulfation was discovered by Baumann around 1875 when he isolated phenyl sulfate from
the urine of a patient who had been treated with phenol. Althoughsulfation was subsequently …

[BOOK][B] Conjugation reactions in drug metabolism: an integrated approach

GJ Mulder - 1990 - books.google.com
… Introduction 1 GJ Mulder … Competition between conjugations for the same substrate 39
GJ Mulder … Conjugation reactions in drug metabolism Edited by GJ Mulder

Pharmacokinetic and pharmacodynamic evaluation of liposomal amikacin for inhalation in cystic fibrosis patients with chronic pseudomonal infection

…, P Minic, LJ Dupont, A Forrest, GJ Mulder… - Antimicrobial agents …, 2009 - Am Soc Microbiol
The pharmacokinetics and pharmacodynamics of a novel liposomal amikacin for inhalation
were evaluated in cystic fibrosis patients with chronic pseudomonas infection. Twenty-four …

Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary fibrosis: an open-label extension study

…, H Santin-Janin, F Aubin, GJ Mulder… - The Lancet …, 2019 - thelancet.com
Background Patients with idiopathic pulmonary fibrosis (IPF) treated with PRM-151, a recombinant
human pentraxin 2 protein, in a phase 2 double-blind, randomised controlled trial had …