[PDF][PDF] Carrier-and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
GR Westerhof, JH Schornagel, I Kathmann… - Molecular …, 1995 - researchgate.net
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate
compounds have been tested in vitm against human and murine ceillines expressing …
compounds have been tested in vitm against human and murine ceillines expressing …
Comparison of different busulfan analogues for depletion of hematopoietic stem cells and promotion of donor-type chimerism in murine bone marrow transplant …
GR Westerhof, RE Ploemacher, A Boudewijn… - Cancer Research, 2000 - AACR
Busulfan (1,4-butanediol dimethanesulfonate, BU) is relatively unique among other standard
chemotherapy compounds in its ability to deplete noncycling primitive stem cells in the host …
chemotherapy compounds in its ability to deplete noncycling primitive stem cells in the host …
[HTML][HTML] Addition of treosulfan to a nonmyeloablative conditioning regimen results in enhanced chimerism and immunologic tolerance in an experimental allogeneic …
…, EJC Rombouts, K Etienne, GR Westerhof… - Biology of Blood and …, 2004 - Elsevier
Treosulfan (l-threitol-1,4-bismethanesulfonate) is an alkylating agent with routine clinical
application in the treatment of ovarian cancer. In this murine study we show that this drug also …
application in the treatment of ovarian cancer. In this murine study we show that this drug also …
[HTML][HTML] Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated …
G Jansen, GR Westerhof, MJ Jarmuszewski… - Journal of Biological …, 1990 - Elsevier
This study reports the isolation and characterization of a variant of the human CCRF-CEM
leukemia cell line that overproduces the carrier protein responsible for the uptake of reduced …
leukemia cell line that overproduces the carrier protein responsible for the uptake of reduced …
Synthesis and biological evaluation of a fluorescent analog of folic acid
TP McAlinden, JB Hynes, SA Patil, GR Westerhof… - Biochemistry, 1991 - ACS Publications
Department of Biochemistry and Molecular Biology, Medical College of Ohio, PO Box 10008,
Toledo, Ohio 43699-0008, Department of Pharmaceutical Sciences, Medical University of …
Toledo, Ohio 43699-0008, Department of Pharmaceutical Sciences, Medical University of …
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein
GR Westerhof, S Rijnboutt, JH Schornagel, HM Pinedo… - Cancer Research, 1995 - AACR
The role of a membrane-associated folate binding protein (mFBP) in transport of folate
analogues was investigated in three epithelial cell lines that were grown in high folate medium …
analogues was investigated in three epithelial cell lines that were grown in high folate medium …
Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier-and receptor-mediated transport systems
GR Westerhof, G Jansen, N van Emmerik, I Kathmann… - Cancer research, 1991 - AACR
L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations
of folates, express a membrane associated folate binding protein (mFBP) in addition to …
of folates, express a membrane associated folate binding protein (mFBP) in addition to …
Expression of a folate binding protein in L1210 cells grown in low folate medium
…, BC Rademaker, BJM Braakhuis, GR Westerhof… - Cancer research, 1989 - AACR
We have isolated variants of L1210 cells (L1210B) expressing, in addition to the “classical”
high affinity/low capacity system for reduced folate uptake, high levels of a membrane-…
high affinity/low capacity system for reduced folate uptake, high levels of a membrane-…
Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice
JD Down, GR Westerhof, A Boudewijn… - Bone marrow …, 1998 - nature.com
Thiotepa (TT) has long been considered for inclusion in clinical bone marrow transplant (BMT)
conditioning regimens in an attempt to prevent allograft rejection and leukemia relapse. …
conditioning regimens in an attempt to prevent allograft rejection and leukemia relapse. …
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors
G Jansen, JH Schornagel, GR Westerhof, G Rijksen… - Cancer research, 1990 - AACR
N 10 -Propargyl-5,8-dideazafolic acid (CB3717) and 2-desamino-2-methyl-N 10 -propargyl-5,8-dideazafolic
acid (ICI-198,583) are potent folate-based inhibitors of thymidylate synthase…
acid (ICI-198,583) are potent folate-based inhibitors of thymidylate synthase…