… Koszalka. June 2000. Antiviral benzimidazole nucleoside analogues and a method for their
… Koszalka. 1999. Development of novel benzimdazole riboside compounds for treatment of …

Several 2-substituted α-d- and α-l-lyxofuranosyl and 5-deoxylyxofuranosyl derivatives of 5,6-dichloro-2-(isopropylamino)-1-(β-l-ribofuranosyl)benzimidazole
(1263W94) and 2,5,6-…

Thomas A. Krenitsky,* George W. Koszalka, and Joel V. Tuttle abstract: An improved method
for the enzymatic synthesis of purine nucleosides is described. Pyrimidine nucleosides …

Background: Purine nucleoside phosphorylase (PNP) from Escherichia coli is a hexameric
enzyme that catalyzes the reversible phosphorolysis of 6-amino and 6-oxopurine (2′-deoxy)…

The three-dimensional structure of thymidine phosphorylase from Escherichia coli has been
determined at 2.8 A resolution using multiple-isomorphous-replacement techniques. The …

… Ferris, RE Dornsife, SC Stanat, JC Drach, LB Townsend, and GW Koszalka. 2002. Potent and
… Koszalka. 1999. Development of novel benzimdazole riboside compounds for treatment of …

HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination
therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV …

Racemic 2', 3'-dideoxy-3/-thianucleosides were resolved by enzyme-catalyzed hydrolysis of
their butyrate ester derivatives. Recently, we required the enantiomers of the important …

GW4511, GW4751, and GW3011 showed IC 50 values ≤2 nM against wild type HIV-1 and
<10 nM against 16 mutants. They were particularly potent against NNRTI-resistant viruses …

A variety of imidazo [4, 5-c] pyridines (3-deazapurines) were synthesized. With use of these
aglycons as pentosyl acceptors, the corresponding ribonucleosides and 2'-…