User profiles for G. B. CORCORAN

GB Corcoran

Professor, Pharmaceutical Sciences, Wayne State University
Verified email at wayne.edu
Cited by 4940

Apoptosis: molecular control point in toxicity

GB Corcoran, L Fix, DP Jones, MT Moslen… - Toxicology and applied …, 1994 - Elsevier
… of DNA repair show that doxorubicin and aphidocolin greatly potentiate acetaminophen-induced
liver necrosis and the toxic death of cultured hepatocytes (Kamendulis and Corcoran, …

Mechanism of Action of N-Acetylcysteine in the Protection Against the Hepatotoxicity of Acetaminophen in Rats In Vivo

BH Lauterburg, GB Corcoran… - The Journal of clinical …, 1983 - Am Soc Clin Investig
Corcoran is now located at the Department of Pharmaceutics, The State University of New
York at … Corcoran, GB 1980. Mechanism of protection against acetaminophen-induceci hepatic …

[PDF][PDF] Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine

GB Corcoran, JR Mitchell, YN Vaishnav… - Molecular …, 1980 - researchgate.net
CORCORAN, GB, JR MITCHELL, YN VAISHNAV AND EC HORNING. Evidence that
acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-…

Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass

DE Salazar, GB Corcoran - The American journal of medicine, 1988 - Elsevier
… Wong BK, U S-WE, Corcoran GB: An overfed rat model that reproduces acetaminophen …
Corcoran GB, Wong BK: Obesity as a risk factor in, druginduced organ injury: increased …

Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat

…, JA Timbrell, WR Snodgrass, GB Corcoran III - Science, 1976 - science.org
Acetylhydrazine, a metabolite of isoniazid, a widely used antituberculosis drug, and
isopropylhydrazine, a metabolite of iproniazid, an antidepressant removed from clinical use because …

Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.

GB Corcoran, BK Wong - Journal of Pharmacology and Experimental …, 1986 - ASPET
The revelation that many covalent binding estimates are falsely low due to flawed normalization
discloses that protection by N-acetyl-L-cysteine against acetaminophen hepatotoxicity is …

[PDF][PDF] Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.

GB Corcoran, WJ Racz, CV Smith… - … of Pharmacology and …, 1985 - researchgate.net
Experiments were designed to test whether the protective effect of N-aGetylGysteine against
aGetaminophen hepatotoxicity pre-cedes arylation of tissue or whether protection occurs …

Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver

N Patel, C Joseph, GB Corcoran, SD Ray - Toxicology and applied …, 2010 - Elsevier
The emergence of silymarin (SMN) as a natural remedy for liver diseases, coupled with its
entry into NIH clinical trial, signifies its hepatoprotective potential. SMN is noted for its ability to …

Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen1

…, MW Gurule, RD Yorkin, GB Corcoran - The FASEB …, 1993 - Wiley Online Library
Ca 2+ accumulates in the nucleus and DNA undergoes enzymatic cleavage into
internucleosomelength fragments before acetaminophen and dimethylnitrosamine produce hepatic …

Resveratrol-induced apoptotic death in human U251 glioma cells

…, D Koubi, T Jackson Hunter, GB Corcoran… - Molecular cancer …, 2005 - AACR
Resveratrol (trans-3,4′,5-trihydroxystilbene) is a naturally occurring polyphenolic compound
highly enriched in grapes, peanuts, red wine, and a variety of food sources. Resveratrol …