We have isolated a 16-amino acid peptide from the venom of the marine snail Conus
magus which potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 …

Neuronal nicotinic acetylcholine receptors (nAChRs) with putative α3β4-subunits have
been implicated in the mediation of signaling in various systems, including ganglionic …

In order to investigate the generation of conotoxin diversity, δ-conotoxin sequences from
nine Conus species were analyzed in the context of their phylogeny. Using a standard …

All 500 species of cone snails (Conus) are venomous predators. From a biochemical/genetic
perspective, differences among Conus species may be based on the 50‐200 different …

The competitive antagonist α-conotoxin-MII (α-CTx-MII) is highly selective for the α3β2
neuronal nicotinic receptor. Other receptor subunit combinations (α2β2, α4β2, α3β4) are >200-…

A paralytic peptide, ψ-conotoxin Piiie has been purified and characterized from Conus
purpurascens venom. Electrophysiological studies indicate that the peptide inhibits the nicotinic …

We describe the isolation and characterization of two peptide toxins from Conus ermineus
venom targeted to nicotinic acetylcholine receptors (nAChRs). The peptide structures have …

α-Conotoxin MII, a peptide toxin isolated from Conus magus, antagonizes a subset of neuronal
nicotinic receptors. Rat α3β2 receptors, expressed in Xenopus oocytes, are blocked with …

… vermogen van Cartier om "schepen te leiden naar de ontdekking van nieuwe landen in de
Nieuwe Wereld". [12] Route van Cartier's eerste reis Op 20 april 1534 [13] vertrok Cartier in …

… in the British Museum of the text of Cartier's second voyage that had been published at Paris
… This was partly due no doubt to the absence from the title page of any mention of Cartier's …