An increasing number of examples in the literature suggest that the in vivo duration of drug
action not only depends on macroscopic pharmacokinetic properties like plasma half‐life and …

Bivalent ligands are increasingly important therapeutic agents. Although the naturally occurring
antibodies are predominant, it is becoming more common to combine different antibody …

The fruit and the leaves of Annona muricata (Annonaceae) are used in traditional medicine
for their tranquillizing and sedative properties. Extracts of the plant have been shown to …

Sartans are non-peptide AT 1 receptor antagonists used to treat hypertension and related
pathologies. Their effects on the G protein-dependent responses of angiotensin II (Ang II) were …

Background and Purpose Optimal drug therapy often requires continuing high levels of target
occupancy. Besides the traditional pharmacokinetic contribution, target binding kinetics is …

Calcium is a key intracellular signal that controls manifold cellular processes over a wide
temporal range. The development of calcium‐sensitive fluorescent dyes and proteins …

Importance of the field: It is well established that the in vivo duration of drug action not only
depends on macroscopic pharmacokinetic properties like its plasma half-life, but also on the …

For decades, angiotensin (Ang) II was considered as the end product and the only bioactive
peptide of the renin–angiotensin system (RAS). However, later studies revealed biological …

A deficiency of dopamine in the striatum may contribute to the decline in motor function
associated with aging. We examined the effect of aging on the densities of the D 1 and D 2 …

Drug–receptor interactions are traditionally quantified in terms of affinity and efficacy, but
there is increasing awareness that the drug-on-receptor residence time also affects clinical …