Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
…, D Trisciuoglio, M Desideri, F Cognetti, G Zupi… - Cancer research, 2006 - AACR
Mammalian target of rapamycin (mTOR) is increasingly recognized as a master regulator of
fundamental cellular functions, whose deregulation may underlie neoplastic transformation …
fundamental cellular functions, whose deregulation may underlie neoplastic transformation …
[HTML][HTML] Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
…, E Gilson, A Stoppacciaro, G Zupi… - The Journal of …, 2007 - Am Soc Clin Investig
Functional telomeres are required for the replicability of cancer cells. The G-rich strand of
telomeric DNA can fold into a 4-stranded structure known as the G-quadruplex (G4), whose …
telomeric DNA can fold into a 4-stranded structure known as the G-quadruplex (G4), whose …
Systemic administration of GPI 15427, a novel poly (ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial …
…, M Vergati, I Portarena, W Xu, V Kalish, G Zupi… - Clinical Cancer …, 2003 - AACR
Purpose: Temozolomide (TMZ) is a DNA methylating agent that has shown promising
antitumor activity in recent clinical trials against high grade gliomas, metastatic melanoma, and …
antitumor activity in recent clinical trials against high grade gliomas, metastatic melanoma, and …
[HTML][HTML] c-Myc phosphorylation is required for cellular response to oxidative stress
…, F Fiorentino, A Porrello, G Chiorino, M Loda, G Zupi… - Molecular cell, 2006 - cell.com
Aside from the well-established roles of c-Myc in the regulation of cell cycle, differentiation,
and apoptosis, a recent picture is beginning to emerge linking c-Myc to the regulation of …
and apoptosis, a recent picture is beginning to emerge linking c-Myc to the regulation of …
[HTML][HTML] CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery
…, A Reale, G Riggio, O Sthandier, G Zupi… - Journal of Biological …, 2008 - ASBMB
Our previous data have shown that in L929 mouse fibroblasts the control of methylation
pattern depends in part on poly(ADP-ribosyl)ation and that ADP-ribose polymers (PARs), both …
pattern depends in part on poly(ADP-ribosyl)ation and that ADP-ribose polymers (PARs), both …
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
…, M D'Incalci, C Leonetti, E Gilson, G Zupi… - Nucleic acids …, 2009 - academic.oup.com
Functional telomeres are required to maintain the replicative ability of cancer cells and
represent putative targets for G-quadruplex (G4) ligands. Here, we show that the pentacyclic …
represent putative targets for G-quadruplex (G4) ligands. Here, we show that the pentacyclic …
Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression
…, A Candiloro, Y Ragazzoni, A Orlandi, G Zupi… - European journal of …, 2009 - Elsevier
We examined the autocrine/paracrine role of interleukin-8 (CXCL8) and the functional
significance of CXCL8 receptors, CXCR1 and CXCR2, in human malignant melanoma …
significance of CXCL8 receptors, CXCR1 and CXCR2, in human malignant melanoma …
c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: clinical and experimental findings
…, M Cosimelli, RG Ramsay, B Calabretta, G Zupi - The American journal of …, 2001 - Elsevier
The aim of this study was twofold: to assess the relationship between c-Myb and Bcl-x expression
and to evaluate the prognostic significance of their expression in colorectal carcinoma (…
and to evaluate the prognostic significance of their expression in colorectal carcinoma (…
Bcl‐2 overexpression enhances the metastatic potential of a human breast cancer line
…, A Biroccio, C Leonetti, G Zupi - The FASEB journal, 1997 - Wiley Online Library
Bcl‐2 protein has been shown to contribute to oncogenesis because it can transform and
immortalize cells in cooperation with c‐myc, ras, or viral genes. However, in vivo studies have …
immortalize cells in cooperation with c‐myc, ras, or viral genes. However, in vivo studies have …
Bcl‐2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF‐1mediated transcriptional activity
…, D Ribatti, A Candiloro, A Biroccio, G Zupi… - The FASEB …, 2002 - Wiley Online Library
The aim of this paper was to study the molecular mechanisms by which bcl‐2 increases
hypoxiainduced vascular endothelial growth factor (VEGF) expression. We demonstrated that bcl…
hypoxiainduced vascular endothelial growth factor (VEGF) expression. We demonstrated that bcl…