Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist

…, S Cooper, G Hangoc, GJ Bridger, GW Henson… - Blood, 2003 - ashpublications.org
Stromal cell-derived factor 1 (SDF1/CXCL12) and its cognate receptor, CXCR4, play key
regulatory roles in CD34 + cell trafficking. We investigated whether AMD3100, a selective …

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

…, PJ Maddon, GP Allaway, TP Sakmar, G Henson… - Nature medicine, 1998 - nature.com
The bicyclam AMD3100 (formula weight 830) blocks HIV-1 entry and membrane fusion via
the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal antibody 12G5 …

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

…, E Redpath, G Bridger, GW Henson - Antimicrobial agents …, 2000 - Am Soc Microbiol
AMD-3100, a bicyclam, is a novel agent that uniquely inhibits the entry of human immunodeficiency
virus type 1 (HIV-1) into CD4 + T cells via selective blockade of the chemokine CXCR…

Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

…, S Struyf, JV Damme, JA Esté, G Henson… - The Journal of …, 1997 - rupress.org
Bicyclams are a novel class of antiviral compounds that are highly potent and selective
inhibitors of the replication of HIV-1 and HIV-2. Surprisingly, however, when the prototype …

Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection

…, K Badel, RT MacFarland, GW Henson… - JAIDS Journal of …, 2004 - journals.lww.com
AMD3100 is a CXCR4 receptor inhibitor with anti–HIV-1 activity in vitro. We tested the safety,
pharmacokinetics, and antiviral effect of AMD3100 administered for 10 days by continuous …

AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-γ receptor …

…, A Wuyts, G Bridger, GW Henson… - The Journal of …, 2001 - journals.aai.org
Autoimmune collagen-induced arthritis (CIA) in IFN-γR-deficient DBA/1 mice was shown to
be reduced in severity by treatment with the bicyclam derivative AMD3100, a specific …

Synthesis and structure-activity relationships of phenylenebis (methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size …

…, SA Martellucci, GW Henson… - Journal of medicinal …, 1995 - ACS Publications
We have previously described the potent and selective inhibition of several strains of
human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) by JM2763, an «-propyl-linked …

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4

D Schols, JA Esté, G Henson, E De Clercq - Antiviral research, 1997 - Elsevier
Bicyclams are a novel class of antiviral compounds which are highly potent and selective
inhibitors of the replication of HIV-1 and HIV-2. The prototype compound, AMD3100, has an IC …

Interleukin-3 supports growth of mouse pre-B-cell clones in vitro

R Palacios, G Henson, M Steinmetz, JP McKearn - Nature, 1984 - nature.com
Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered
by the inability to maintain homogeneous populations of precursor cells in vitro. We …

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus

…, J Wang, J Muhammad, JM Patti, G Henson - Bioorganic & medicinal …, 2010 - Elsevier
We herein report a novel double pro-drug approach applied to the anti-HCV agent 2′-β-C-methyl
guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug …