N-formyl peptide receptors (FPRs) are critical regulators of host defense in phagocytes and
are also expressed in epithelia. FPR signaling and function have been extensively studied in …

Epithelial restitution is an essential process that is required to repair barrier function at
mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in …

The mammalian intestine houses a complex microbial community, which influences normal
epithelial growth and development, and is integral to the repair of damaged intestinal …

In response to injury, epithelial cells migrate and proliferate to cover denuded mucosal surfaces
and repair the barrier defect. This process is orchestrated by dynamic crosstalk between …

The mammalian gut microbiota is essential for normal intestinal development, renewal, and
repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in …

Rationale: Chemokine-controlled arterial leukocyte recruitment is a crucial process in
atherosclerosis. Formyl peptide receptor 2 (FPR2) is a chemoattractant receptor that recognizes …

Background : Heart failure following myocardial infarction (MI) remains one of the major
causes of death worldwide, and its treatment is a crucial challenge of cardiovascular medicine. …

IL-1 family members are central mediators of host defense. In this article, we show that the
novel IL-1 family member IL-36γ was expressed during experimental colitis and human …

Intestinal barrier function is regulated by epithelial tight junctions (TJs), structures that
control paracellular permeability. Junctional adhesion molecule-A (JAM-A) is a TJ-associated …

In acute and chronic inflammation, neutrophils and platelets, both of which promote monocyte
recruitment, are often activated simultaneously. We investigated how secretory products of …