[HTML][HTML] Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia

JL Bolton, CM Ruiz, N Rismanchi, GA Sanchez… - Neurobiology of …, 2018 - Elsevier
Early-life adversity increases the risk for emotional disorders such as depression and
schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by our …

Coincident regulation of PLCβ signaling by Gq-coupled and μ-opioid receptors opposes opioid-mediated antinociception

GA Sanchez, EM Jutkiewicz, S Ingram… - Molecular pharmacology, 2022 - ASPET
Pain management is an important problem worldwide. The current frontline approach for pain
management is the use of opioid analgesics. The primary analgesic target of opioids is the …

Augmented seizure susceptibility and hippocampal epileptogenesis in a translational mouse model of febrile status epilepticus

KD Chen, AM Hall, MM Garcia‐Curran, GA Sanchez… - …, 2021 - Wiley Online Library
Objective Prolonged fever‐induced seizures (febrile status epilepticus [FSE]) during early
childhood increase the risk for later epilepsy, but the underlying mechanisms are incompletely …

Hyper-diversity of CRH interneurons in mouse hippocampus

BG Gunn, GA Sanchez, G Lynch, TZ Baram… - Brain Structure and …, 2019 - Springer
Hippocampal inhibitory interneurons comprise an anatomically, neurochemically and
electrophysiologically diverse population of cells that are essential for the generation of the …

[HTML][HTML] Immunoblot screening of CRISPR/Cas9-mediated gene knockouts without selection

JA Estep, EL Sternburg, GA Sanchez… - BMC molecular …, 2016 - Springer
Background Targeted genomic editing using the CRISPR/Cas9 methodology has opened
exciting new avenues in probing gene function in virtually any model system, including …

Biasing of G-signaling with Small Molecules as a Novel Therapeutic Approach to Improve Opioid-mediated Antinociception

G Sanchez - 2023 - deepblue.lib.umich.edu
Opioid analgesics are widely used as a treatment option for pain management and relief.
However, the misuse of opioid analgesics has contributed to the current opioid epidemic in the …

Blockade of selective Gβγ signaling pathway by gallein decreases development of opioid tolerance

AV Smrcka, G Sanchez, EMM Jutkiewicz - 2023 - ASPET
ID 18253 Poster Board 406 The μ-opioid receptor (MOR) is a G i -protein-coupled receptor (GPCR)
responsible for opioid-induced analgesia and undesired effects such as constipation, …

Diseño de una máquina curvadora de cuatro rodillos para la empresa Servimet SAS

…, VG Romero Racedo, JD Sánchez Reyes… - 2020 - manglar.uninorte.edu.co
At Barranquilla, the metal-mechanic sector responsible of tank production that satisfy API
650 regulations for petrochemical industry storage has some limitations that make more …

[PDF][PDF] Escuela Agrícola Panamericana, Zamorano Food Science and Technology Department Food Science and Technology Major

C Pork, B Sausages - bdigital.zamorano.edu
Actualmente, los consumidores buscan alimentos que ofrezcan una buena experiencia
sensorial, aporten beneficios nutricionales y ayuden a la salud. La industria del plátano genera …

[PDF][PDF] Dexamethasone Attenuates Hyperexcitability Provoked by Experimental Febrile Status

MM Garcia-Curran, AM Hall, KP Patterson - eNeuro, 6 (6), 2019 - core.ac.uk
The role of neuroinflammation in the mechanisms of epilepsy development is important
because inflammatory mediators provide tractable targets for intervention. Inflammation is …