An isopropylalaninyl monoamidate phenyl monoester prodrug of tenofovir (GS 7340) was
prepared, and its in vitro antiviral activity, metabolism, and pharmacokinetics in dogs were …

The mechanism for the bimolecular reaction of meso-tetrakis (2, 6-dichlorophenyl)
porphinato-oxo-manganese-(IV),[(Cl8TPP) MnIV (0)], with alkenes has been investigated bykinetics …

PMPA, an acyclic nucleoside phosphonate analog, is a potent inhibitor of HIV. In the cells,
PMPA is efficiently phosphorylated by intracellular kinases to produce PMPApp, the …

… Gabriel Birkus, Nilima Kutty, Gong-Xin He, Andrew Mulato, William Lee, Martin McDermott
… Lee WA, Gong-Xin H, Eisenberg E, Cihlar T, Swaminathan S, Mulato A, and Cundy K (2005) …

The introduction of human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs)
markedly improved the clinical outcome and control of HIV-1 infection. However, cross-…

2‘-Deoxyguanosine (G) analogues carrying various hydrophobic substituents in the N 2 and
C 8 positions were synthesized and introduced through solid-phase synthesis into 15-mer …

The mechanism of the oxidation of alkenes by r-BuOOH in the presence of iron (III)
tetraphenylporphyrins has been explored (CH2C12 sovent). The alkenes,«'¿-stilbene and (Z)-l, 2-bis …

0 3^-CSC- 8b investigation a similarly structural approach was directed toward the synthesis
of liquid-crystalline compounds containing a crown ether unit. Since compound 1 (Chart I) …

GS-8374 is a novel bis-tetrahydrofuran HIV-1 protease (PR) inhibitor (PI) with a unique
diethylphosphonate moiety. It was selected from a series of analogs containing various di(alkyl)…

A series of 15-mer oligodeoxynucleotide analogues were synthesized, and their thrombin
inhibitory activities in vitro and in vivo were evaluated. These oligodeoxynucleotide analogues …