[HTML][HTML] Phosphatidylserine receptors enhance SARS-CoV-2 infection
…, E Christakou, P Kursula, D Micklem, G Gausdal… - PLoS …, 2021 - journals.plos.org
Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through
virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly …
virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly …
[PDF][PDF] AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells
…, M Chisamore, D Micklem, H Gabra, G Gausdal… - Cell Reports …, 2022 - cell.com
… To assess the TME from each treatment group, we performed … and its TME from each
treatment group and annotated with … the same treatment group were calculated and compared …
treatment group and annotated with … the same treatment group were calculated and compared …
Association of AXL and PD-L1 expression with clinical outcomes in patients with advanced renal cell carcinoma treated with PD-1 blockade
…, IC Moreno, G Lacroix, JB Lorens, G Gausdal… - Clinical Cancer …, 2021 - AACR
Purpose: A minority of patients currently respond to single-agent immune-checkpoint blockade
(ICB), and strategies to increase response rates are urgently needed. AXL is a receptor …
(ICB), and strategies to increase response rates are urgently needed. AXL is a receptor …
[HTML][HTML] AXL targeting abrogates autophagic flux and induces immunogenic cell death in drug-resistant cancer cells
Introduction Acquired cancer therapy resistance evolves under selection pressure of immune
surveillance and favors mechanisms that promote drug resistance through cell survival and …
surveillance and favors mechanisms that promote drug resistance through cell survival and …
AXL targeting overcomes human lung cancer cell resistance to NK-and CTL-mediated cytotoxicity
…, S Corgnac, D Collares, G Meurice, G Gausdal… - Cancer immunology …, 2019 - AACR
Immune resistance may arise from both genetic instability and tumor heterogeneity.
Microenvironmental stresses such as hypoxia and various resistance mechanisms promote …
Microenvironmental stresses such as hypoxia and various resistance mechanisms promote …
[HTML][HTML] A functional role of GAS6/TAM in nonalcoholic steatohepatitis progression implicates AXL as therapeutic target
…, I Graupera, M Coll, A Colell, G Gausdal… - Cellular and molecular …, 2020 - Elsevier
Background and Aims GAS6 signaling, through the TAM receptor tyrosine kinases AXL and
MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM …
MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM …
[HTML][HTML] Antiviral screening of multiple compounds against Ebola virus
In light of the recent outbreak of Ebola virus (EBOV) disease in West Africa, there have been
renewed efforts to search for effective antiviral countermeasures. A range of compounds …
renewed efforts to search for effective antiviral countermeasures. A range of compounds …
Clear cell renal cell carcinoma is linked to epithelial‐to‐mesenchymal transition and to fibrosis
…, K Finne, T Osman, MM Ibrahim, G Gausdal… - Physiological …, 2017 - Wiley Online Library
Clear cell renal cell carcinoma (cc RCC ) represents the most common type of kidney cancer
with high mortality in its advanced stages. Our study aim was to explore the correlation …
with high mortality in its advanced stages. Our study aim was to explore the correlation …
[HTML][HTML] The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner
L Oftedal, L Myhren, J Jokela, G Gausdal… - … et Biophysica Acta (BBA …, 2012 - Elsevier
The two novel cyanobacterial cyclic lipopeptides, anabaenolysin (Abl) A and B permeabilised
mammalian cells, leading to necrotic death. Abl A was a more potent haemolysin than …
mammalian cells, leading to necrotic death. Abl A was a more potent haemolysin than …
Mutated HRAS activates YAP1–AXL signaling to drive metastasis of head and neck cancer
…, M Wainer, L Vtorov, I Allon, O Cohen, G Gausdal… - Cancer research, 2023 - AACR
Mutant HRAS drives metastasis of head and neck cancer by switching off the Hippo
pathway to activate the YAP1–AXL axis and to stimulate lymphovascular angiogenesis. …
pathway to activate the YAP1–AXL axis and to stimulate lymphovascular angiogenesis. …