Herpesviruses are members of a diverse family of viruses that colonize all vertebrates from
fish to mammals. Although more than one hundred herpesviruses exist, all are nearly …

“Lysosomotropic” cationic drugs are known to concentrate in acidic cell compartments due to
low retro-diffusion of the protonated molecule (ion trapping); they draw water by an osmotic …

Inherited chromosomally integrated human herpesvirus-6 (iciHHV-6) results in the germ-line
transmission of the HHV-6 genome. Every somatic cell of iciHHV-6+ individuals contains …

Bradykinin-related peptides, the kinins, are blood-derived peptides that stimulate 2 G protein–coupled
receptors, the B 1 and B 2 receptors (B 1 R, B 2 R). The pharmacologic and …

Procaine and some other basic drugs reportedly induce vacuolization of various cell types.
We addressed the concentration-effect and structure-activity relationships as well as the …

Cationic drugs frequently exhibit large apparent volumes of distribution, consistent with various
forms of cellular sequestration. The contributions of organelles and metabolic processes …

Human herpesvirus-6A (HHV-6A) and HHV-6B integrate their genomes into the telomeres
of human chromosomes, however, the mechanisms leading to integration remain unknown. …

Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses
that are associated with various diseases including seizures and encephalitis. The HHV-…

Kinins are the small and fragile hydrophilic peptides related to bradykinin (BK) and derived
from circulating kininogens via the action of kallikreins. Kinins bind to the preformed and …

The bradykinin B 2 receptor is a heptahelical receptor regulated by a cycle of phosphorylation,
endocytosis, and extensive recycling at the cell surface following agonist stimulation. B-…