User profiles for H E Melikian

Haley Melikian

UMASS Chan Medical School
Verified email at umassmed.edu
Cited by 3048

Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation

HE Melikian - Pharmacology & therapeutics, 2004 - Elsevier
… laboratory demonstrate that NET expressed in PC12 cells rapidly internalizes at rates
comparable to DAT (3–5%/min), consistent with active endocytic trafficking (Holton and Melikian, …

Membrane trafficking regulates the activity of the human dopamine transporter

HE Melikian, KM Buckley - Journal of Neuroscience, 1999 - Soc Neuroscience
The trafficking of synaptic proteins is unquestionably a major determinant of the properties
of synaptic transmission. Here, we present a detailed analysis of the downregulation and …

Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function

W Paradee, HE Melikian, DL Rasmussen, A Kenneson… - Neuroscience, 1999 - Elsevier
Fragile X syndrome is an X-linked form of mental retardation resulting from the absence of
expression of the fragile X mental retardation 1 gene. The encoded protein is a ribosome-…

[HTML][HTML] The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines

MK Loder, HE Melikian - Journal of Biological Chemistry, 2003 - ASBMB
The dopamine transporter (DAT) removes dopamine from the extracellular milieu and is
potently inhibited by number of psychoactive drugs, including cocaine, amphetamines, and …

Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies

Y Qian, HE Melikian, DB Rye, AI Levey… - Journal of …, 1995 - Soc Neuroscience
… Louis, MO) by maleimide cross-linking to free sulfhydryl groups as previously described (Melikian
et al., 1994). For production of antifusion protein antibody CT-2, a 102 bp segment of …

Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization

KL Holton, MK Loder, HE Melikian - Nature neuroscience, 2005 - nature.com
Neurotransmitter transporters are critical for synaptic neurotransmitter inactivation.
Transporter inhibitors markedly increase the duration and magnitude of synaptic transmission, …

[PDF][PDF] Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition.

HE Melikian, S Ramamoorthy, CG Tate… - Molecular …, 1996 - Citeseer
The role of N-glycosylation in the expression, stability, and ligand recognition by the cocaine-
and antidepressant-sensitive human norepinephrine transporter(hNET) was assessed in …

Regulation of neuronal function by protein trafficking: a role for the endosomal pathway

KM Buckley, HE Melikian, CJ Provoda… - The Journal of …, 2000 - Wiley Online Library
Protein trafficking plays a central role in many aspects of neuronal function, from the release
of neurotransmitters by exocytosis and the recycling of synaptic vesicle proteins to the …

The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking

…, LM Lifshitz, HH Sitte, HE Melikian - Journal of …, 2011 - Soc Neuroscience
Dopaminergic signaling and plasticity are essential to numerous CNS functions and
pathologies, including movement, cognition, and addiction. The amphetamine- and cocaine-…

Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton

…, C Standley, KE Fogarty, HE Melikian - Journal of …, 2013 - Soc Neuroscience
Dopaminergic signaling profoundly impacts rewarding behaviors, movement, and executive
function. The presynaptic dopamine (DA) transporter (DAT) recaptures released DA, thereby …