[HTML][HTML] Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)

S Mangmool, H Kurose - Toxins, 2011 - mdpi.com
… This process called G i/o protein-dependent effect of PTX, has a slow onset (at least 1-2 h)
and requires a low concentration of the toxin. A second involves binding of the B-oligomer of …

[HTML][HTML] Cardiac fibrosis and fibroblasts

H Kurose - Cells, 2021 - mdpi.com
… In the heart, aquaporin transfers H 2 O 2 from the extracellular space to the cytosol [89]. H
2 O 2 … Since H 2 O 2 is generated from the superoxide anion (O 2 − ) produced by NADPH …

[PDF][PDF] LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death

…, S Shimizu, E Mori, J Kudoh, N Shimizu, H Kurose… - Molecular cell, 2002 - cell.com
… , LTRPC2, activated by micromolar levels of H 2 O 2 and agents that produce reactive …
revealed physiological involvement of "native" LTRPC2 in H 2 O 2 - and TNFα-induced Ca 2…

[HTML][HTML] Therapeutic targets for the treatment of cardiac fibrosis and cancer: focusing on TGF-β signaling

…, T Luangmonkong, S Mangmool, H Kurose - Frontiers in …, 2020 - frontiersin.org
Transforming growth factor-β (TGF-β) is a common mediator of cancer progression and
fibrosis. Fibrosis can be a significant pathology in multiple organs, including the heart. In this …

FLAC/PFC coupled numerical simulation of AE in large-scale underground excavations

…, M Minami, T Maejima, Y Tasaka, H Kurose - International Journal of …, 2007 - Elsevier
Acoustic emission (AE) and microseismic (MS) events are indicators of rock fracturing or
damage as the rock is brought to failure at high stress. By capturing the AE/MS events, …

TRPC3 and TRPC6 are essential for angiotensin II‐induced cardiac hypertrophy

…, H Sumimoto, Y Sato, Y Mori, T Nagao, H Kurose - The EMBO …, 2006 - embopress.org
… II (100 nM), and a portion of cells was infected with DGKβ for 48 h before Ang II stimulation.
(B, C) … for 6 h. The fold activation was calculated by the values of untreated cells set as 1. (F–…

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

…, M Yamamoto, M Suematsu, H Kurose… - Nature chemical …, 2012 - nature.com
… Western blotting of H-Ras, flotillin 1 and S-guanylated H-Ras for the raft fraction and active
H-Ras, S-guanylated H-Ras and H-Ras for the nonraft fraction in the presence or absence of 8…

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

…, K Watanabe, A Uemura, H Kurose… - Proceedings of the …, 2009 - National Acad Sciences
… (r) to ventricular wall thickness (h) was significantly decreased in echocardiography in mid
… Six-weeks TAC operation induced an r/h ratio increase characteristic of dilated hypertrophy (…

[HTML][HTML] Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and …

MG Eason, H Kurose, BD Holt, JR Raymond… - Journal of Biological …, 1992 - Elsevier
… fetal bovine serum for 24 h. These concentrations of CTX and … with CTX and PTX for 24 h
were prepared, then incubated … 1%digitonin by gentle rotation for 1 h at 4 "C. The mixture was …

[HTML][HTML] TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor

…, H Koizumi, T Uede, G Tsujimoto, H Kurose… - Journal of Biological …, 2004 - ASBMB
… [ 3 H]inositol (in 1 ml) and 0.1% BSA. PTX treatment of the cells was performed by adding the
toxin (100 ng/ml) to the medium 18 h … at 60 C for 1 h before being counted for radioactivity. …