The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein
associated with resistance of human tumor cells to cytotoxic drugs. We have investigated how …

… GJ, Broxterman, HJ, ci ill. Correlation of multidrug resistance with decreased drug
accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in …

Transfection of multidrug resistance proteins (MRPs) MRP1 and MRP2 in human ovarian
carcinoma 2008 cells conferred a marked level of resistance to short-term (1–4 h) exposure to …

Anticancer drug resistance almost invariably emerges and poses major obstacles towards
curative therapy of various human malignancies. In the current review we will distinguish …

In animal models, growth of tumors and their metastases is dependent on factors that
stimulate vessel formation (angiogenesis). Most clinical studies confirm the importance of …

Multidrug resistance (MDR), especially that associated with overexpression of MDR1 and its
product, P-glycoprotein (Pgp), is thought to play a role in the outcome of therapy for some …

Purpose: Resistance to antiangiogenic tyrosine kinase inhibitors such as sunitinib is an
important clinical problem, but its underlying mechanisms are largely unknown. We analyzed …

Multiple molecular, cellular, micro-environmental and systemic causes of anticancer drug
resistance have been identified during the last 25 years. At the same time, genome-wide …

Coagulation abnormalities, including an increased platelet turnover, are frequently found in
patients with cancer. Because platelets secrete angiogenic factors on activation, this study …

Multidrug resistance (MDR) to anticancer drugs is a major cause of treatment failure in cancer.
The lung resistance protein LRP is a newly described protein related to MDR in several in …