Substrate‐dependent bidirectional modulation of P‐glycoprotein‐mediated drug resistance by erlotinib

K Noguchi, H Kawahara, A Kaji, K Katayama… - Cancer …, 2009 - Wiley Online Library
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) inhibit the function
of certain adenosine triphosphate (ATP)‐binding cassette transporters, including P‐…

Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules

…, Y Demizu, R Sugihara, A Ichino, H Kawahara… - Molecular …, 2017 - ASPET
Development of novel small molecules that selectively degrade pathogenic proteins would
provide an important advance in targeted therapy. Recently, we have devised a series of …

Pharmacological interaction with sunitinib is abolished by a germ‐line mutation (1291T>C) of BCRP/ABCG2 gene

H Kawahara, K Noguchi, K Katayama… - Cancer …, 2010 - Wiley Online Library
Sunitinib malate (Sutent, SU11248) is a small‐molecule multitargeted tyrosine kinase inhibitor
(TKI) used for the treatment of renal cell carcinoma and imatinib‐resistant gastrointestinal …

A photo-activatable peptide mimicking functions of apolipoprotein AI

H Kawahara, N Miyashita, K Tachibana… - Biological and …, 2019 - jstage.jst.go.jp
Apolipoprotein AI (apoA-I) plays a critical role in high-density lipoprotein (HDL) biogenesis,
function and structural dynamics. Peptides that mimic apoA-I have a short amphipathic α-…

Lipopolysaccharide and lipoteichoic acid influence milk production ability via different early responses in bovine mammary epithelial cells

Y Tsugami, H Wakasa, M Kawahara… - Experimental Cell …, 2021 - Elsevier
Lipopolysaccharide (LPS) and lipoteichoic acid (LTA) are cell wall components of Escherichia
coli and Staphylococcus aureus, which cause clinical and subclinical mastitis, respectively…

Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells

Y Tsugami, H Wakasa, M Kawahara, A Watanabe… - Cell and tissue …, 2021 - Springer
Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy
cows. Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly …

Effect of summer heat stress on gene expression in bovine uterine endometrial tissues

H Bai, H Ukita, M Kawahara, T Mitani… - Animal Science …, 2020 - Wiley Online Library
Heat stress negatively affects reproductive functions in cows. Increased temperature disturbs
fetal development in utero. However, the effect of heat stress on uterine endometrial tissues …

Conserved roles of fibroblast growth factor receptor 2 signaling in the regulation of inner cell mass development in bovine blastocysts

…, M Nagano, M Takahashi, M Kawahara - Molecular …, 2016 - Wiley Online Library
A common process during preimplantation mammalian development is blastocyst formation,
which utilizes signaling through fibroblast growth factor receptor 2 (FGFR2), yet the …

[HTML][HTML] CyclosporinA derivative as therapeutic candidate for Alport syndrome by inducing mutant type IV collagen secretion

…, H Kojima, M Kamura, S Kaseda, T Kawahara… - Kidney360, 2023 - journals.lww.com
Background Type IV collagen α3, 4, 5 (α345 (IV)) is an obligate trimer that is secreted to form
a collagen network, which is the structural foundation of basement membrane. Mutation in …

The infrared Doppler (IRD) instrument for the Subaru telescope: instrument description and commissioning results

…, H Genda, A Fukui, Y Fujii, H Kawahara… - Ground-based and …, 2018 - spiedigitallibrary.org
The Infrared Doppler (IRD) instrument is a fiber-fed high-resolution NIR spectrometer for the
Subaru telescope covering the Y,J,H-bands simultaneously with a maximum spectral …