Nitroxyl (HNO) may be formed endogenously by uncoupled nitric-oxide (NO) synthases,
enzymatic reduction of NO or as product of vascular nitroglycerin bioactivation. The established …

Dysfunction of vascular nitric oxide (NO)/cGMP signaling is believed to contribute essentially
to various cardiovascular disorders. Besides synthesis and/or bioavailability of endothelial …

The role of nitric oxide (NO) and guanosine 3′,5′-cyclic monophosphate (cyclic GMP) in
cellular regulation of endothelin-1 (ET-1) secretion was investigated in cultured porcine aortic …

Nitrosothiols are increasingly regarded as important participants in a range of physiological
processes, yet little is known about their biological generation. Nitrosothiols can be formed …

Electronic cigarette refill liquids are commercially provided with a wide variety of flavoring
agents. A recent study suggested that several common flavors may scavenge nitric oxide (NO) …

Systemic knockout of adipose triglyceride lipase (ATGL), the pivotal enzyme of triglyceride
lipolysis, results in a murine phenotype that is characterized by progredient cardiac steatosis …

Cardiac oxidative stress has been implicated in the pathogenesis of hypertrophy, cardiomyopathy
and heart failure. Systemic deletion of the gene encoding adipose triglyceride lipase (…

Aims Nitroglycerin (GTN) acts through release of a nitric oxide (NO)-related activator of
soluble guanylate cyclase in vascular smooth muscle. Besides enzymatic GTN bioactivation …

Background and purpose: Vascular tolerance to nitroglycerin (GTN) may be caused by
impaired GTN bioactivation due to inactivation of mitochondrial aldehyde dehydrogenase (ALDH2…

Systemic deletion of the gene encoding for adipose triglyceride lipase (ATGL) in mice leads
to severe cardiac dysfunction due to massive accumulation of neutral lipids in …