[HTML][HTML] Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration

V Talman, H Ruskoaho - Cell and tissue research, 2016 - Springer
Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

GATA transcription factors in the developing and adult heart

…, H Tokola, R Kerkelä, H Ruskoaho - Cardiovascular …, 2004 - academic.oup.com
During the past decade, emerging evidence has accumulated of different nuclear transcription
factors in regulation of cardiac development and growth as well as in cardiac hypertrophy …

Cardiac hormones as diagnostic tools in heart failure

H Ruskoaho - Endocrine reviews, 2003 - academic.oup.com
In patients with heart failure, plasma levels of atrial natriuretic peptide (ANP), B-type
natriuretic peptide (BNP), and the N-terminal fragments of their prohormones (N-ANP and N-BNP) …

Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

…, J Piuhola, J Rysä, M Tóth, H Ruskoaho - Circulation …, 2002 - Am Heart Assoc
The orphan receptor APJ and its recently identified endogenous ligand, apelin, exhibit high
levels of mRNA expression in the heart. However, the functional importance of apelin in the …

Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching

P Kinnunen, O Vuolteenaho, H Ruskoaho - Endocrinology, 1993 - academic.oup.com
Ventricular hypertrophy is characterized by augmentation of the synthesis and storage of
atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). To evaluate in vitro the …

Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure

…, Z Lakó-Futó, R dechatel, H Ruskoaho… - Biochemical and …, 2003 - Elsevier
The orphan receptor APJ and its recently identified endogenous ligand, apelin, are expressed
in the heart. However, their importance in the human cardiovascular system is not known. …

Effects of dexmedetomidine, a selective α2‐adrenoceptor agonist, on hemodynamic control mechanisms

…, M Koulu, R Ponkilainen, H Ruskoaho… - Clinical …, 1989 - Wiley Online Library
Dexmedetomidine, a selective α 2 ‐adrenoceptor agonist, was administered to five healthy
male volunteers in single intravenous doses of 12.5, 25, 50, and 75 µg as part of a placebo‐…

Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice

…, A Muona, M Ilves, H Ruskoaho… - Proceedings of the …, 2001 - National Acad Sciences
Type XV collagen occurs widely in the basement membrane zones of tissues, but its function
is unknown. To understand the biological role of this protein, a null mutation in the Col15a1 …

A role for cardiac mast cells in the pathogenesis of hypertensive heart disease

N Shiota, J Rysä, PT Kovanen, H Ruskoaho… - Journal of …, 2003 - journals.lww.com
Design By examining spontaneously hypertensive rats (SHRs) during their entire lifespan,
we attempted to define the role of mast cells in the induction of cardiac hypertrophy and …

Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A-and B-type natriuretic peptides

…, K Peuhkurinen, J Leipala, H Ruskoaho… - Clinical …, 2004 - academic.oup.com
Background: The N-terminal fragments of A- and B-type natriuretic peptides (NT-proANP
and NT-proBNP) are powerful markers of cardiac function. The current assays require …