ROS stress in cancer cells and therapeutic implications

H Pelicano, D Carney, P Huang - Drug resistance updates, 2004 - Elsevier
Reactive oxygen species (ROS) are constantly generated and eliminated in the biological
system, and play important roles in a variety of normal biochemical functions and abnormal …

[HTML][HTML] The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo

L Fu, H Pelicano, J Liu, P Huang, CC Lee - cell, 2002 - cell.com
The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here
that mice deficient in the mPer2 gene are cancer prone. After γ radiation, these mice show a …

[PDF][PDF] Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

…, Y Zhou, H Zhang, Y Demizu, Z Chen, H Pelicano… - Cancer cell, 2006 - cell.com
Reactive oxygen species (ROS) stimulate cell proliferation and induce genetic instability, and
their increase in cancer cells is often viewed as an adverse event. Here, we show that such …

Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia

R Xu, H Pelicano, Y Zhou, JS Carew, L Feng… - Cancer research, 2005 - AACR
Cancer cells generally exhibit increased glycolysis for ATP generation (the Warburg effect)
due in part to mitochondrial respiration injury and hypoxia, which are frequently associated …

Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species

J Alexandre, Y Hu, W Lu, H Pelicano, P Huang - Cancer research, 2007 - AACR
Generation of reactive oxygen species (ROS) has been observed in cancer cells treated with
paclitaxel, but the underlying mechanisms and therapeutic implications remain unclear. In …

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

…, D Trachootham, J Liu, G Chen, H Pelicano… - Nature cell …, 2012 - nature.com
Tissue stromal cells interact with leukaemia cells and profoundly affect their viability and drug
sensitivity. Here we show a biochemical mechanism by which bone marrow stromal cells …

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ

…, R Sasaki, L Feng, JS Carew, W Lu, H Pelicano… - The EMBO …, 2005 - embopress.org
Mitochondrial DNA (mtDNA) mutations and deletions are frequently observed in cancer,
and contribute to altered energy metabolism, increased reactive oxygen species (ROS), and …

[HTML][HTML] K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

…, M Ogasawara, D Trachootham, L Feng, H Pelicano… - Cell research, 2012 - nature.com
Increased aerobic glycolysis and oxidative stress are important features of cancer cell
metabolism, but the underlying biochemical and molecular mechanisms remain elusive. Using a …

[HTML][HTML] Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression

…, M Qiu, D Wang, D Xu, Z Zhou, H Pelicano… - Journal of experimental …, 2016 - Springer
Background Long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor
progression. However, the role and molecular mechanism of lncRNA XIST in gastric cancer …

[HTML][HTML] Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression

…, Z Zeng, Z Pan, Y Yuan, F Wang, H Pelicano… - Theranostics, 2017 - ncbi.nlm.nih.gov
Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including
colorectal cancer (CRC). However, the role of lncRNA in CRC liver metastasis remains …