The multidrug resistance protein MRP1 functions as an ATP-dependent conjugate export
pump and confers multidrug resistance. We cloned MRP2 (symbol ABCC2), a MRP family …

ATP-dependent transport of glutathione and glucuronate conjugates from hepatocytes into
bile is mediated by a distinct member of the ATP-binding cassette superfamily. We have …

Human kidney proximal tubule epithelia express the ATP-dependent export pump for anionic
conjugates encoded by the MRP2 (cMRP/cMOAT) gene (symbol ABCC2). MRP2, the …

Tumor neovasculature substantially derives from sprouting of existing vessels, whereas the
functional contribution of bone marrow-derived progenitors to neovessels remains …

In nontumorigenic mammary epithelial cells (EpH4), transforming growth factor-β (TGFβ1)
causes cell cycle arrest/apoptosis, but induces epitheliomesenchymal transition (EMT) in Ha-…

Background/Aims: Expression and localization of human hepatocellular transporters and of
radixin, cross-linking actin with some membrane transporters, may change in cholestatic liver …

Random peptide phage display libraries have been employed widely to identify protein–protein
interactions, using as targets either purified proteins, intact cells, or organs. To isolate …

Recent studies on the subcellular distribution of cytoplasmic plaque proteins of intercellular
junctions have revealed that a number of such proteins can also occur in the cyto- and the …

Absence of a functional multidrug resistance protein 2 (MRP2; symbol ABCC2) from the
hepatocyte canalicular membrane is the molecular basis of Dubin- Johnson syndrome, an …

The anucleate prismoid fiber cells of the eye lens are densely packed to form a tissue in
which the plasma membranes and their associated cytoplasmic coat form a single giant cell-cell …