Transcriptional regulation of the human μ-opioid receptor gene by interleukin-6
C Börner, J Kraus, H Schröder, H Ammer, V Höllt - Molecular pharmacology, 2004 - ASPET
Inflammatory pain is counteracted by a number of physiological processes. For example,
opioid receptors, which are present on peripheral terminals of sensory neurons, are activated …
opioid receptors, which are present on peripheral terminals of sensory neurons, are activated …
Chronic morphine treatment inhibits opioid receptor desensitization and internalization
DA Eisinger, H Ammer, R Schulz - Journal of Neuroscience, 2002 - Soc Neuroscience
Chronic opioid receptor (OR) activation by morphine causes distinct cellular adaptations
responsible for the development of tolerance. The present study examines the effect of chronic …
responsible for the development of tolerance. The present study examines the effect of chronic …
Bicyclic peptide library screening for the identification of Gαi protein modulators
…, A Koley, CA Rhodes, H Ammer… - Journal of Medicinal …, 2023 - ACS Publications
Noncanonical G protein activation and inactivation, particularly for the Gαi/s protein
subfamilies, have long been a focus of chemical research. Combinatorial libraries were already …
subfamilies, have long been a focus of chemical research. Combinatorial libraries were already …
A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway
…, EA Willer, P Bihari, G Jürgenliemk, H Ammer… - Journal of Molecular and …, 2012 - Elsevier
Endothelial hyperpermeability followed by edema formation is a hallmark of many severe
disorders. Effective drugs directly targeting endothelial barrier function are widely lacking. We …
disorders. Effective drugs directly targeting endothelial barrier function are widely lacking. We …
Retinoic acid‐induced differentiation of human neuroblastoma SH‐SY5Y cells is associated with changes in the abundance of G proteins
H Ammer, R Schulz - Journal of neurochemistry, 1994 - Wiley Online Library
Western blot analysis, using subtype‐specific anti‐G protein antibodies, revealed the presence
of the following G protein subunits in human neuroblastoma SH‐ SY5Y cells: Gaα, G i α1, …
of the following G protein subunits in human neuroblastoma SH‐ SY5Y cells: Gaα, G i α1, …
δ-Opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases
DA Eisinger, H Ammer - Cellular signalling, 2008 - Elsevier
Integrin-mediated cell adherence to extracellular matrix proteins results in stimulation of
ERK1/2 activity, a mechanism involving focal adhesion tyrosine kinases (pp125FAK, Pyk-2) and …
ERK1/2 activity, a mechanism involving focal adhesion tyrosine kinases (pp125FAK, Pyk-2) and …
Targeting Gαi/s proteins with peptidyl nucleotide exchange modulators
…, EM Pfeil, SK Annala, H Ammer… - ACS chemical …, 2022 - ACS Publications
Chemical probes that specifically modulate the activity of heterotrimeric G proteins provide
excellent tools for investigating G protein-mediated cell signaling. Herein, we report a family …
excellent tools for investigating G protein-mediated cell signaling. Herein, we report a family …
δ-Opioid receptor-stimulated Akt signaling in neuroblastoma× glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation
A Heiss, H Ammer, DA Eisinger - Experimental cell research, 2009 - Elsevier
δ-Opioid receptor (DOR) agonists possess cytoprotective properties, an effect associated
with activation of the “pro-survival” kinase Akt. Here we delineate the signal transduction …
with activation of the “pro-survival” kinase Akt. Here we delineate the signal transduction …
[HTML][HTML] Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network
IR Weingaertner, S Koutnik, H Ammer - PLoS One, 2013 - journals.plos.org
Background There is increasing evidence that opioid analgesics may interfere with tumour
growth. It is currently thought that these effects are mediated by transactivation of receptor …
growth. It is currently thought that these effects are mediated by transactivation of receptor …
Enhanced stimulatory adenylyl cyclase signaling during opioid dependence is associated with a reduction in palmitoylated Gsα
H Ammer, R Schulz - Molecular Pharmacology, 1997 - ASPET
Chronic opioid treatment of stably μ-opioid receptor transfected human mammary epidermoid
A431 carcinoma cells (clone A431/μ13) results in sensitization of adenylyl cyclase (AC), a …
A431 carcinoma cells (clone A431/μ13) results in sensitization of adenylyl cyclase (AC), a …